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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xrcc2tm1Pmc
targeted mutation 1, Peter J McKinnon
MGI:3654106
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Xrcc2tm1Pmc/Xrcc2tm1Pmc involves: 129S1/Sv * C57BL/6 MGI:3655286
cx2
 		Xrcc2tm1Pmc/Xrcc2tm1Pmc
Atmtm1Pmc/Atmtm1Pmc 		involves: 129S1/Sv MGI:3655295
cx3
 		Trp53tm1Tyj/Trp53tm1Tyj
Xrcc2tm1Pmc/Xrcc2tm1Pmc 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 MGI:3655298
cx4
 		Trp53tm1Tyj/Trp53+
Xrcc2tm1Pmc/Xrcc2tm1Pmc 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 MGI:3655347


Genotype
MGI:3655286
hm1
Allelic
Composition		 Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xrcc2tm1Pmc mutation (1 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cellular
increased apoptosis ( J:111068 )
• abundant apoptosis of proliferating cells is observed, particularly in the forebrain and hindbrain structures in embryos isolated at later stages




Genotype
MGI:3655295
cx2
Allelic
Composition		 Xrcc2tm1Pmc/Xrcc2tm1Pmc
Atmtm1Pmc/Atmtm1Pmc
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Pmc mutation (0 available); any Atm mutation (170 available)
Xrcc2tm1Pmc mutation (1 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:111068 )
• embryos are recovered at the same frequency as Xrcc2 single mutants indicating Atm deficiency does not provide a survival advantage




Genotype
MGI:3655298
cx3
Allelic
Composition		 Trp53tm1Tyj/Trp53tm1Tyj
Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
Xrcc2tm1Pmc mutation (1 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:111068 )
• mice are less robust than Lig4/Trp53 double homozygotes and often die perinatally of indeterminate causes

growth/size/body
decreased body weight ( J:111068 )
• mice are smaller and less robust than wild-type littermates

nervous system
decreased neuron apoptosis ( J:111068 )
• apoptosis is markedly reduced in double mutants

neoplasm
increased tumor incidence ( J:111068 )
• surviving double mutants all develop multiple tumor types with a rapid onset and with different tumor types present by 10 weeks of age
increased lymphoma incidence ( J:111068 )
• these are B220 negative and distinct from the pro-B cell lymphomas
increased T cell derived lymphoma incidence ( J:111068 )
• thymomas contain multiple chromosomal rearrangements but no recurring chromosomal rearrangements are observed in primary tumors

integument

cellular
decreased neuron apoptosis ( J:111068 )
• apoptosis is markedly reduced in double mutants

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:111068 )
• thymomas contain multiple chromosomal rearrangements but no recurring chromosomal rearrangements are observed in primary tumors

hematopoietic system
increased T cell derived lymphoma incidence ( J:111068 )
• thymomas contain multiple chromosomal rearrangements but no recurring chromosomal rearrangements are observed in primary tumors

immune system
increased T cell derived lymphoma incidence ( J:111068 )
• thymomas contain multiple chromosomal rearrangements but no recurring chromosomal rearrangements are observed in primary tumors




Genotype
MGI:3655347
cx4
Allelic
Composition		 Trp53tm1Tyj/Trp53+
Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
Xrcc2tm1Pmc mutation (1 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:111068 )
• mice are smaller and less robust than wild-type littermates

neoplasm

endocrine/exocrine glands

hematopoietic system

immune system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory