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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccr9tm1Lov
targeted mutation 1, Paul E Love
MGI:3654108
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccr9tm1Lov/Ccr9tm1Lov involves: 129 MGI:3655385


Genotype
MGI:3655385
hm1
Allelic
Composition		 Ccr9tm1Lov/Ccr9tm1Lov
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr9tm1Lov mutation (1 available); any Ccr9 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased gamma-delta T cell number ( J:110846 )
• null mice have ~2-fold increased numbers of gammadelta-TCR+ cells in the spleen and lymph nodes compared to controls
decreased lymphocyte cell number ( J:110846 )
• bone marrow cells from null mice transplanted into lethally-irradiated Rag1 mice show lower proliferation than wild-type BMC 2 months following transplantation
abnormal gamma-delta intraepithelial T cell morphology ( J:110846 )
• percentage of gammadelta-TCR+ intraepithelial cells are increased in the large intestine and decreased in the small intestine compared to controls
decreased CD8-positive, gamma-delta intraepithelial T cell number ( J:110846 )
• percentage of CDalphabeta8+ intraepithelial lymphocytes is reduced in the small intestine

immune system
increased gamma-delta T cell number ( J:110846 )
• null mice have ~2-fold increased numbers of gammadelta-TCR+ cells in the spleen and lymph nodes compared to controls
decreased lymphocyte cell number ( J:110846 )
• bone marrow cells from null mice transplanted into lethally-irradiated Rag1 mice show lower proliferation than wild-type BMC 2 months following transplantation
abnormal gamma-delta intraepithelial T cell morphology ( J:110846 )
• percentage of gammadelta-TCR+ intraepithelial cells are increased in the large intestine and decreased in the small intestine compared to controls
decreased CD8-positive, gamma-delta intraepithelial T cell number ( J:110846 )
• percentage of CDalphabeta8+ intraepithelial lymphocytes is reduced in the small intestine




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory