All Phenotypes Irak1<tm1Wpfl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Irak1^tm1Wpfl
targeted mutation 1, Wai-Ping Fung-Leung
MGI:3654141

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irak1^tm1Wpfl/Irak1^tm1Wpfl	involves: 129P2/OlaHsd * C57BL/6J	MGI:3654552

Allelic Composition	Irak1^tm1Wpfl/Irak1^tm1Wpfl
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1^tm1Wpfl mutation (0 available); any Irak1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:110860 )

• in response to IL-1, MEFs show defective acitivation of Jnk and p38; Tnfa-induced Jnk activity is comparable to Irak-sufficient control cells from Cd8a^tm1Mak mice

• IL-1 induction of NF-kappaB is defective in Irak1-deficient cells

• induction of IL-6 is defective in Irak1-deficient cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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