cellular
• in response to IL-1, MEFs show defective acitivation of Jnk and p38; Tnfa-induced Jnk activity is comparable to Irak-sufficient control cells from Cd8atm1Mak mice
• IL-1 induction of NF-kappaB is defective in Irak1-deficient cells
• induction of IL-6 is defective in Irak1-deficient cells
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