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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Irak1tm1Wpfl
targeted mutation 1, Wai-Ping Fung-Leung
MGI:3654141
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Irak1tm1Wpfl/Irak1tm1Wpfl involves: 129P2/OlaHsd * C57BL/6J MGI:3654552


Genotype
MGI:3654552
hm1
Allelic
Composition
Irak1tm1Wpfl/Irak1tm1Wpfl
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1tm1Wpfl mutation (0 available); any Irak1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in response to IL-1, MEFs show defective acitivation of Jnk and p38; Tnfa-induced Jnk activity is comparable to Irak-sufficient control cells from Cd8atm1Mak mice
• IL-1 induction of NF-kappaB is defective in Irak1-deficient cells
• induction of IL-6 is defective in Irak1-deficient cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory