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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tiraptm1Aki
targeted mutation 1, Shizuo Akira
MGI:3654146
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tiraptm1Aki/Tiraptm1Aki B6.129P2-Tiraptm1Aki MGI:3718578
hm2
 		Tiraptm1Aki/Tiraptm1Aki involves: 129P2/OlaHsd * C57BL/6 MGI:3654451


Genotype
MGI:3718578
hm1
Allelic
Composition		 Tiraptm1Aki/Tiraptm1Aki
Genetic
Background		 B6.129P2-Tiraptm1Aki
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tiraptm1Aki mutation (1 available); any Tirap mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell physiology ( J:118954 )
• following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 and IL-6 relative to wild-type mice
decreased interleukin-12b secretion ( J:118954 )
• following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 and IL-6 relative to wild-type mice
decreased interleukin-6 secretion ( J:118954 )
• following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 and IL-6 relative to wild-type mice




Genotype
MGI:3654451
hm2
Allelic
Composition		 Tiraptm1Aki/Tiraptm1Aki
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tiraptm1Aki mutation (1 available); any Tirap mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG3 level ( J:137066 )
• significantly reduced in serum at 7 and 11 weeks of age
abnormal level of surface class II molecules ( J:111205 )
• proliferation and augmentation of MHC class II expression is severely impaired in mutants compared to wild-type
abnormal cytokine secretion ( J:111205 )
• exposure to LPS does not stimulate production of Tnfa. Il-6 or Il-12 in Tirap-null mice but does in wild-type and death from LPS-shock occurs with in 96 hours
• production of Il-12, Il-6 and Tnfa is strongly impaired in mutants when exposed to TLR2 ligands like MALP-2 or S. aureus peptidogylcan

hematopoietic system
decreased IgG3 level ( J:137066 )
• significantly reduced in serum at 7 and 11 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory