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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gata6tm2.1Sad
targeted mutation 2.1, Stephen A Duncan
MGI:3654150
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gata6tm2.1Sad/Gata6tm2.1Sad involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL MGI:3662653
cn2
 		Gata6tm2.1Sad/Gata6tm2.2Sad
Tg(EIIa-cre)C5379Lmgd/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL MGI:3662656
cn3
 		Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Vil1-cre)997Gum/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL MGI:3662654
cn4
 		Gata4tm1.1Sad/Gata4tm1.1Sad
Gata6tm2.1Sad/Gata6+
Tg(Wt1-cre)1Jbeb/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5562928
cn5
 		Gata4tm1.1Sad/Gata4tm1.1Sad
Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Wt1-cre)1Jbeb/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5562926
cn6
 		Gata4tm1.1Sad/Gata4+
Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Wt1-cre)1Jbeb/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5562927
cn7
 		Gata6tm2.1Sad/Gata6tm2.1Sad
Gli1tm1Alj/Gli1tm1Alj
Tg(Prrx1-cre)1Cjt/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J MGI:5550093
cn8
 		Gata6tm2.1Sad/Gata6tm2.1Sad
Shhtm2Amc/Shhtm2Amc
Tg(Prrx1-cre)1Cjt/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J MGI:5550094
cn9
 		Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Prrx1-cre)1Cjt/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J MGI:5550091


Genotype
MGI:3662653
hm1
Allelic
Composition		 Gata6tm2.1Sad/Gata6tm2.1Sad
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:111388 )
• viable and fertile with no gross malformations




Genotype
MGI:3662656
cn2
Allelic
Composition		 Gata6tm2.1Sad/Gata6tm2.2Sad
Tg(EIIa-cre)C5379Lmgd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Gata6tm2.2Sad mutation (0 available); any Gata6 mutation (35 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:111388 )
• between E8.5 and E11.5 all Cre positive double mutants appear to be partially resorbed empty decidual masses




Genotype
MGI:3662654
cn3
Allelic
Composition		 Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:111388 )
• matings of 4 of 5 males carrying the Cre transgene to homozygous females produced no offspring homozygous for the floxed allele and Cre positive




Genotype
MGI:5562928
cn4
Allelic
Composition		 Gata4tm1.1Sad/Gata4tm1.1Sad
Gata6tm2.1Sad/Gata6+
Tg(Wt1-cre)1Jbeb/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation (1 available); any Gata4 mutation (36 available)
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Tg(Wt1-cre)1Jbeb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:206877 )
• mutants are viable through E15.5, with a small number recovered at weaning

cardiovascular system
abnormal heart layer morphology ( J:206877 )
• a statistically significant decrease in sub-epicardicardial endothelial cells is observed at E13.5




Genotype
MGI:5562926
cn5
Allelic
Composition		 Gata4tm1.1Sad/Gata4tm1.1Sad
Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Wt1-cre)1Jbeb/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation (1 available); any Gata4 mutation (36 available)
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Tg(Wt1-cre)1Jbeb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:206877 )
• normal Mendelian ratios are observed through E14.5, but all mutants are necrotic by E15.5; no living animals are present at weaning

cardiovascular system
abnormal cardiovascular development ( J:206877 )
• at E13.5, hearts display some coronary plexus formation near the base with significantly vessel decreased spreading towards the apex
abnormal heart layer morphology ( J:206877 )
• numbers of sub-epicardial endothelial cells are decreased by <90% at E13.5 compared to wild-type
• numbers of epicardial cells are not different from wild type at E13.5
• 3-fold fewer inner-myocardial endothelial cells are detected in mutant hearts at E13.5
thin myocardium ( J:206877 )
• one third of E13.5 hearts display myocardial thinning (<2 SD from mean of wild-type)
thin ventricular wall ( J:206877 )
• mutants show decreased ventricular thickness compared to wild-type
decreased fetal cardiomyocyte proliferation ( J:206877 )
• at E13.5, myocardial proliferation is decreased compared to wild-type, contribution to the observed myocardial thinning

limbs/digits/tail
polydactyly ( J:206877 )
• hind limb polydactyly is observed in E14.5 embryos

cellular
decreased fetal cardiomyocyte proliferation ( J:206877 )
• at E13.5, myocardial proliferation is decreased compared to wild-type, contribution to the observed myocardial thinning

muscle
thin myocardium ( J:206877 )
• one third of E13.5 hearts display myocardial thinning (<2 SD from mean of wild-type)
decreased fetal cardiomyocyte proliferation ( J:206877 )
• at E13.5, myocardial proliferation is decreased compared to wild-type, contribution to the observed myocardial thinning




Genotype
MGI:5562927
cn6
Allelic
Composition		 Gata4tm1.1Sad/Gata4+
Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Wt1-cre)1Jbeb/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation (1 available); any Gata4 mutation (36 available)
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Tg(Wt1-cre)1Jbeb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:206877 )
• mutants are viable through E15.5, with a small number recovered at weaning

cardiovascular system
abnormal heart layer morphology ( J:206877 )
• a statistically significant decrease in sub-epicardicardial endothelial cells is observed at E13.5




Genotype
MGI:5550093
cn7
Allelic
Composition		 Gata6tm2.1Sad/Gata6tm2.1Sad
Gli1tm1Alj/Gli1tm1Alj
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Gli1tm1Alj mutation (0 available); any Gli1 mutation (49 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
polydactyly ( J:205405 )
• hindlimb polydactytly




Genotype
MGI:5550094
cn8
Allelic
Composition		 Gata6tm2.1Sad/Gata6tm2.1Sad
Shhtm2Amc/Shhtm2Amc
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Shhtm2Amc mutation (1 available); any Shh mutation (48 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
hindlimb oligodactyly ( J:205405 )
• hindlimbs have four digits




Genotype
MGI:5550091
cn9
Allelic
Composition		 Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
preaxial polydactyly ( J:205405 )
• 100% penetrance of preaxial hindlimb polydactyly with a variable number of supernumerary digits
• forelimb digits are not affected




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory