About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gata6tm2.1Sad
targeted mutation 2.1, Stephen A Duncan
MGI:3654150
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gata6tm2.1Sad/Gata6tm2.1Sad involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL MGI:3662653
cn2
 		Gata6tm2.1Sad/Gata6tm2.2Sad
Tg(EIIa-cre)C5379Lmgd/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL MGI:3662656
cn3
 		Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Vil1-cre)997Gum/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL MGI:3662654
cn4
 		Gata4tm1.1Sad/Gata4tm1.1Sad
Gata6tm2.1Sad/Gata6+
Tg(Wt1-cre)1Jbeb/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5562928
cn5
 		Gata4tm1.1Sad/Gata4tm1.1Sad
Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Wt1-cre)1Jbeb/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5562926
cn6
 		Gata4tm1.1Sad/Gata4+
Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Wt1-cre)1Jbeb/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5562927
cn7
 		Gata6tm2.1Sad/Gata6tm2.1Sad
Gli1tm1Alj/Gli1tm1Alj
Tg(Prrx1-cre)1Cjt/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J MGI:5550093
cn8
 		Gata6tm2.1Sad/Gata6tm2.1Sad
Shhtm2Amc/Shhtm2Amc
Tg(Prrx1-cre)1Cjt/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J MGI:5550094
cn9
 		Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Prrx1-cre)1Cjt/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J MGI:5550091


Genotype
MGI:3662653
hm1
Allelic
Composition		 Gata6tm2.1Sad/Gata6tm2.1Sad
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:111388 )
• viable and fertile with no gross malformations




Genotype
MGI:3662656
cn2
Allelic
Composition		 Gata6tm2.1Sad/Gata6tm2.2Sad
Tg(EIIa-cre)C5379Lmgd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Gata6tm2.2Sad mutation (0 available); any Gata6 mutation (35 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:111388 )
• between E8.5 and E11.5 all Cre positive double mutants appear to be partially resorbed empty decidual masses




Genotype
MGI:3662654
cn3
Allelic
Composition		 Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:111388 )
• matings of 4 of 5 males carrying the Cre transgene to homozygous females produced no offspring homozygous for the floxed allele and Cre positive




Genotype
MGI:5562928
cn4
Allelic
Composition		 Gata4tm1.1Sad/Gata4tm1.1Sad
Gata6tm2.1Sad/Gata6+
Tg(Wt1-cre)1Jbeb/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation (1 available); any Gata4 mutation (36 available)
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Tg(Wt1-cre)1Jbeb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:206877 )
• mutants are viable through E15.5, with a small number recovered at weaning

cardiovascular system
abnormal heart layer morphology ( J:206877 )
• a statistically significant decrease in sub-epicardicardial endothelial cells is observed at E13.5




Genotype
MGI:5562926
cn5
Allelic
Composition		 Gata4tm1.1Sad/Gata4tm1.1Sad
Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Wt1-cre)1Jbeb/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation (1 available); any Gata4 mutation (36 available)
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Tg(Wt1-cre)1Jbeb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:206877 )
• normal Mendelian ratios are observed through E14.5, but all mutants are necrotic by E15.5; no living animals are present at weaning

cardiovascular system
abnormal cardiovascular development ( J:206877 )
• at E13.5, hearts display some coronary plexus formation near the base with significantly vessel decreased spreading towards the apex
abnormal heart layer morphology ( J:206877 )
• numbers of sub-epicardial endothelial cells are decreased by <90% at E13.5 compared to wild-type
• numbers of epicardial cells are not different from wild type at E13.5
• 3-fold fewer inner-myocardial endothelial cells are detected in mutant hearts at E13.5
thin myocardium ( J:206877 )
• one third of E13.5 hearts display myocardial thinning (<2 SD from mean of wild-type)
thin ventricular wall ( J:206877 )
• mutants show decreased ventricular thickness compared to wild-type
decreased fetal cardiomyocyte proliferation ( J:206877 )
• at E13.5, myocardial proliferation is decreased compared to wild-type, contribution to the observed myocardial thinning

limbs/digits/tail
polydactyly ( J:206877 )
• hind limb polydactyly is observed in E14.5 embryos

cellular
decreased fetal cardiomyocyte proliferation ( J:206877 )
• at E13.5, myocardial proliferation is decreased compared to wild-type, contribution to the observed myocardial thinning

muscle
thin myocardium ( J:206877 )
• one third of E13.5 hearts display myocardial thinning (<2 SD from mean of wild-type)
decreased fetal cardiomyocyte proliferation ( J:206877 )
• at E13.5, myocardial proliferation is decreased compared to wild-type, contribution to the observed myocardial thinning




Genotype
MGI:5562927
cn6
Allelic
Composition		 Gata4tm1.1Sad/Gata4+
Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Wt1-cre)1Jbeb/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation (1 available); any Gata4 mutation (36 available)
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Tg(Wt1-cre)1Jbeb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:206877 )
• mutants are viable through E15.5, with a small number recovered at weaning

cardiovascular system
abnormal heart layer morphology ( J:206877 )
• a statistically significant decrease in sub-epicardicardial endothelial cells is observed at E13.5




Genotype
MGI:5550093
cn7
Allelic
Composition		 Gata6tm2.1Sad/Gata6tm2.1Sad
Gli1tm1Alj/Gli1tm1Alj
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Gli1tm1Alj mutation (0 available); any Gli1 mutation (49 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
polydactyly ( J:205405 )
• hindlimb polydactytly




Genotype
MGI:5550094
cn8
Allelic
Composition		 Gata6tm2.1Sad/Gata6tm2.1Sad
Shhtm2Amc/Shhtm2Amc
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Shhtm2Amc mutation (1 available); any Shh mutation (48 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
hindlimb oligodactyly ( J:205405 )
• hindlimbs have four digits




Genotype
MGI:5550091
cn9
Allelic
Composition		 Gata6tm2.1Sad/Gata6tm2.1Sad
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation (1 available); any Gata6 mutation (35 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
preaxial polydactyly ( J:205405 )
• 100% penetrance of preaxial hindlimb polydactyly with a variable number of supernumerary digits
• forelimb digits are not affected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory