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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ubdtm1Smwe
targeted mutation 1, Sherman M Weissman
MGI:3654319
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ubdtm1Smwe/Ubdtm1Smwe B6.129S6-Ubdtm1Smwe MGI:3687506


Genotype
MGI:3687506
hm1
Allelic
Composition		 Ubdtm1Smwe/Ubdtm1Smwe
Genetic
Background		 B6.129S6-Ubdtm1Smwe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubdtm1Smwe mutation (0 available); any Ubd mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphocyte physiology ( J:110321 )
• increased apoptosis among lymphocytes but distribution of cell types is normal
increased susceptibility to bacterial infection ( J:110321 )
• increased susceptibility to low doses of endotoxin

cellular
increased apoptosis ( J:110321 )
• of lymphocytes

hematopoietic system
abnormal lymphocyte physiology ( J:110321 )
• increased apoptosis among lymphocytes but distribution of cell types is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory