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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ube2ntm1Aki
targeted mutation 1, Shizuo Akira
MGI:3655236
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ube2ntm1Aki/Ube2ntm1Aki involves: 129P2/OlaHsd * C57BL/6 MGI:3656032
cn2
 		Ube2ntm1Aki/Ube2ntm1Aki
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3656028
cn3
 		Cd19tm1(cre)Cgn/Cd19+
Ube2ntm1Aki/Ube2ntm1Aki 		involves: 129P2/OlaHsd * C57BL/6 MGI:3656029


Genotype
MGI:3656032
hm1
Allelic
Composition		 Ube2ntm1Aki/Ube2ntm1Aki
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ube2ntm1Aki mutation (0 available); any Ube2n mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:112287 )
• mice are born in expected ratios and show no obvious abnormalities




Genotype
MGI:3656028
cn2
Allelic
Composition		 Ube2ntm1Aki/Ube2ntm1Aki
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Ube2ntm1Aki mutation (0 available); any Ube2n mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:112287 )
• upon TLR ligand stimulation, macrophages produce less TNF,Il-6 and Il-12p40 than those in conrols

hematopoietic system
abnormal macrophage physiology ( J:112287 )
• upon TLR ligand stimulation, macrophages produce less TNF,Il-6 and Il-12p40 than those in conrols




Genotype
MGI:3656029
cn3
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Ube2ntm1Aki/Ube2ntm1Aki
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Ube2ntm1Aki mutation (0 available); any Ube2n mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:112287 )
• B cells expressing B220, CD38 and CD21 are present in lower numbers
• fewer B cells enter S phase after stimulation with anti-IgM, anti-CD40, LPS or CpG DNA
abnormal spleen marginal zone morphology ( J:112287 )
• width of marginal zone B cell area is smaller than in controls
decreased marginal zone B cell number ( J:112287 )
• mice have a much lower frequency of B220+CD21hiCD23low marginal zone B cells
abnormal B cell physiology ( J:112287 )
• mice show defective MAP kinase activation in B cells
increased B cell apoptosis ( J:112287 )
• more mutant B cells undergo apoptosis ex vivo even after stimulation with LPS, CpG DNA or anti-CD40
decreased B cell proliferation ( J:112287 )
• B cells stimulated with LPS or CpG DNA show a lower proliferative response than controls
decreased immunoglobulin level ( J:112287 )
• all isotypes except IgG2a and IgG2b are significantly lower than in controls
abnormal humoral immune response ( J:112287 )
• after immunization with TNP-ficoll or TNP-chicken gammaglobulin mice produce less serum TNP-specific IgM and IgG3

hematopoietic system
decreased B cell number ( J:112287 )
• B cells expressing B220, CD38 and CD21 are present in lower numbers
• fewer B cells enter S phase after stimulation with anti-IgM, anti-CD40, LPS or CpG DNA
abnormal spleen marginal zone morphology ( J:112287 )
• width of marginal zone B cell area is smaller than in controls
decreased marginal zone B cell number ( J:112287 )
• mice have a much lower frequency of B220+CD21hiCD23low marginal zone B cells
abnormal B cell physiology ( J:112287 )
• mice show defective MAP kinase activation in B cells
increased B cell apoptosis ( J:112287 )
• more mutant B cells undergo apoptosis ex vivo even after stimulation with LPS, CpG DNA or anti-CD40
decreased B cell proliferation ( J:112287 )
• B cells stimulated with LPS or CpG DNA show a lower proliferative response than controls
decreased immunoglobulin level ( J:112287 )
• all isotypes except IgG2a and IgG2b are significantly lower than in controls

cellular
increased B cell apoptosis ( J:112287 )
• more mutant B cells undergo apoptosis ex vivo even after stimulation with LPS, CpG DNA or anti-CD40
decreased B cell proliferation ( J:112287 )
• B cells stimulated with LPS or CpG DNA show a lower proliferative response than controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory