Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gars1Gt(XM256)6Byg gene trap 6, BayGenomics MGI:3655818 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no nervous system phenotype; no axonal degeneration is seen, with large-caliber axons and neuromuscular synapses with normal morphology present and normal nerve conduction velocities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mutants are born at the expected Mendelian ratios, indicating rescue of the embryonic lethality observed in compound heterozygotes without the transgene
• while embryonic lethality is rescued with the transgene, severity of neuropathy is similar to single GarsC201R heterozygotes
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• mutants exhibit lower body weights than single GarsGt(XM256)6Byg heterozygotes or wild-type mice
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| N |
• mutants exhibit normal numbers of myelinated axons in the motor or sensory branch of the fremoral nerve
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• neuromuscular junctions have regions of immature morphology or denervation, similar to single GarsC201R heterozygotes
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• mutants exhibit reduced nerve conduction velocities, but they are similar to single GarsC201R heterozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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