Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Sln)26Peri
• Allele Name: transgene insertion 26, Muthu Periasamy
• Allele ID: MGI:3655879
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Sln)26Peri/0	involves: C57BL/6	MGI:3655880

Genotype
MGI:3655880

tg1

• Allelic Composition: Tg(Myh6-Sln)26Peri/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased cardiac muscle contractility ( J:108309 )

• hearts show a significant decrease in the maximum rate of contraction (+dP/dt)

• the force-frequency relation of hearts is shifted to the right, indicating decreased contractility, however at very high stimulation frequencies (11 Hz), significant differences in contraction are not seen

• speed of contraction of heart muscle preparations is slower at low frequency, but not different at 14 Hz

abnormal cardiac muscle relaxation ( J:108309 )

• hearts show a significant decrease in the maximum rate of relaxation (-dP/dt)

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:108309 )

• exhibit a decrease in calcium affinity and rate of calcium uptake in heart ventricles, indicating a decrease in sarco(endoplasmic)reticulum calcium transport function

• ventricular myocytes show a decrease in calcium transient amplitude by 57%

muscle

decreased cardiac muscle contractility ( J:108309 )

• hearts show a significant decrease in the maximum rate of contraction (+dP/dt)

• the force-frequency relation of hearts is shifted to the right, indicating decreased contractility, however at very high stimulation frequencies (11 Hz), significant differences in contraction are not seen

• speed of contraction of heart muscle preparations is slower at low frequency, but not different at 14 Hz

abnormal cardiac muscle relaxation ( J:108309 )

• hearts show a significant decrease in the maximum rate of relaxation (-dP/dt)