Phenotypes associated with this allele

• Allele Symbol: Ptch2^tm1Hui
• Allele Name: targeted mutation 1, Chi-Chung Hui
• Allele ID: MGI:3656034
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptch2^tm1Hui/Ptch2^tm1Hui	involves: 129S1/Sv * 129X1/SvJ	MGI:3662660
ht2	Ptch2^tm1Hui/Ptch2^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3662661

Genotype
MGI:3662660

hm1

• Allelic Composition: Ptch2^tm1Hui/Ptch2^tm1Hui
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:112169 )

N • both sexes are fertile and males have normal testis histology

nervous system

nervous system phenotype ( J:112169 )

N • cerebellar morphology and histology are similar to wild-type

integument

alopecia ( J:112169 )

• seen in 48% of adult males, no hair loss is seen in females

dermal hyperplasia ( J:112169 )

• dermal hyperplasia is seen in 70% of male mice

epidermal hyperplasia ( J:112169 )

• seen in 60% of male mice

skin lesions ( J:112169 )

• 80% of males develop some form of skin lesion consistently located on the dorsal and front paw skin and characterized by dermal hyperplasia, epidermal hyperplasia, hair follicle loss, and/or ulceration

• seen only in male mice

• lesions develop earlier (6 - 7 months of age) than in heterozygous male mice

spontaneous skin ulceration ( J:112169 )

• 15% of males develop spontaneous skin ulcers

Genotype
MGI:3662661

ht2

• Allelic Composition: Ptch2^tm1Hui/Ptch2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

integument

alopecia ( J:112169 )

• seen in 21% of adult males, no hair loss is seen in females

abnormal dermal layer morphology ( J:112169 )

dermal hyperplasia ( J:112169 )

• dermal hyperplasia is seen in 61% of male mice

epidermal hyperplasia ( J:112169 )

• seen in 29% of male mice

skin lesions ( J:112169 )

• 74% of males develop some form of skin lesion consistently located on the dorsal and front paw skin and characterized by dermal hyperplasia, epidermal hyperplasia, hair follicle loss, and/or ulceration

• seen only in male mice

• lesions develop later (9 - 10 months of age) than in homozygous male mice

spontaneous skin ulceration ( J:112169 )

• 3% of males develop spontaneous skin ulcers