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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(PF4-tTA/VP16)42Kra
transgene insertion 42, Katya Ravid
MGI:3656262
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(PF4-tTA/VP16)42Kra/0
Tg(tetO-Aurkb,lacZ)41Kra/0 		FVB/NJ-Tg(tetO-Aurkb,lacZ)41Kra Tg(PF4-tTA/VP16)42Kra MGI:3656381


Genotype
MGI:3656381
cx1
Allelic
Composition		 Tg(PF4-tTA/VP16)42Kra/0
Tg(tetO-Aurkb,lacZ)41Kra/0
Genetic
Background		 FVB/NJ-Tg(tetO-Aurkb,lacZ)41Kra Tg(PF4-tTA/VP16)42Kra
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(PF4-tTA/VP16)42Kra mutation (1 available)
Tg(tetO-Aurkb,lacZ)41Kra mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal platelet physiology ( J:104239 )
• after LPS treatment, mice show accumulation of platelets in the liver and lungs in the induced (doxycycline removed) state

hematopoietic system
abnormal thrombopoiesis ( J:104239 )
• induced mice show no increase in platelet number compared to control
abnormal platelet physiology ( J:104239 )
• after LPS treatment, mice show accumulation of platelets in the liver and lungs in the induced (doxycycline removed) state

immune system
abnormal thrombopoiesis ( J:104239 )
• induced mice show no increase in platelet number compared to control




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory