All Phenotypes Rfng<tm1Tfv> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rfng^tm1Tfv
targeted mutation 1, Thomas F Vogt
MGI:3662620

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Lfng^tm1Rjo/Lfng^tm1Rjo Mfng^tm1Seco/Mfng^tm1Seco Rfng^tm1Tfv/Rfng^tm1Tfv	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ	MGI:3849432
cx2	En1^tm1Alj/En1^tm1Alj Rfng^tm1Tfv/Rfng⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3849436
cx3	En1^tm1Alj/En1^tm1Alj Rfng^tm1Tfv/Rfng^tm1Tfv	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3849435

Allelic Composition	Lfng^tm1Rjo/Lfng^tm1Rjo Mfng^tm1Seco/Mfng^tm1Seco Rfng^tm1Tfv/Rfng^tm1Tfv
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfng^tm1Rjo mutation (0 available); any Lfng mutation (32 available)
Mfng^tm1Seco mutation (1 available); any Mfng mutation (35 available)
Rfng^tm1Tfv mutation (0 available); any Rfng mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:149312 )

• fewer than expected are found at weaning however survivors are viable and fertile

postnatal lethality, incomplete penetrance ( J:149312 )

• fewer than expected are found at weaning

• reduction in numbers found at weaning is not greater than that of Lfng^tm1Rjo single homozygous littermates

skeleton

abnormal skeleton morphology ( J:149312 )

• skeleton phenotype is not significantly different from that of Lfng^tm1Rjo single homozygous mice

decreased caudal vertebrae number ( J:149312 )

abnormal rib morphology ( J:149312 )

limbs/digits/tail

limbs/digits/tail phenotype ( J:149312 )

N	• unlike in chick embryo experiments, no limb abnormalities are seen

decreased caudal vertebrae number ( J:149312 )

Allelic Composition	En1^tm1Alj/En1^tm1Alj Rfng^tm1Tfv/Rfng⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (34 available)
Rfng^tm1Tfv mutation (0 available); any Rfng mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal apical ectodermal ridge morphology ( J:149312 )

• at E10.5 the AER appears flattened and ventrally expanded

• by E11.5, clefts and bifurcations are seen along with ventral anterior nubs

• 2 distinct ectodermal ridges are present

embryo

abnormal apical ectodermal ridge morphology ( J:149312 )

• at E10.5 the AER appears flattened and ventrally expanded

• by E11.5, clefts and bifurcations are seen along with ventral anterior nubs

• 2 distinct ectodermal ridges are present

Allelic Composition	En1^tm1Alj/En1^tm1Alj Rfng^tm1Tfv/Rfng^tm1Tfv
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb development ( J:149312 )

• indistinguishable from mice with one wild-type Rfng allele at all stages examined

abnormal apical ectodermal ridge morphology ( J:149312 )

• at E10.5 the AER appears flattened and ventrally expanded

• by E11.5, clefts and bifurcations are seen along with ventral anterior nubs

• 2 distinct ectodermal ridges are present

embryo

abnormal apical ectodermal ridge morphology ( J:149312 )

• at E10.5 the AER appears flattened and ventrally expanded

• by E11.5, clefts and bifurcations are seen along with ventral anterior nubs

• 2 distinct ectodermal ridges are present

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