Phenotypes associated with this allele

• Allele Symbol: Ret^tm1Kln
• Allele Name: targeted mutation 1, Rudiger Klein
• Allele ID: MGI:3662623
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ret^tm1Kln/Ret^tm1Kln Tg(Nes-cre)1Kln/0	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL	MGI:3662906
cn2	Lhx1^tm1Tmj/Lhx1^+ Ret^tm1Kln/Ret^tm1Kln Tg(Nes-cre)1Kln/0	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL	MGI:3662908
cn3	Ret^tm1Kln/Ret^tm1Kln Slc6a3^tm1(cre)Xz/Slc6a3^+	involves: 129S1/Sv	MGI:5440833

Genotype
MGI:3662906

cn1

• Allelic Composition: Ret^tm1Kln/Ret^tm1Kln; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal innervation pattern to muscle ( J:110955 )

• mutants have peroneal nerves (PN) of reduced length (~40% of control) at E11.5 and nerves are reduced in complexity at E12.5; diameter of peroneal nerve is also reduced

• phenotype at E12.5 is somewhat less severe than in Ret^tm1Kln; Tg(Pgk1-cre)1Lni mice

limbs/digits/tail

clubfoot ( J:110955 )

• clubbed feet are observed in mutants after birth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
clubfoot		DOID:11836	OMIM:119800	J:110955

Genotype
MGI:3662908

cn2

• Allelic Composition: Lhx1^tm1Tmj/Lhx1⁺; Ret^tm1Kln/Ret^tm1Kln; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL

nervous system

abnormal axon guidance ( J:110955 )

• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve

• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls

• phenotype of mice is more severe than in wild-type Lhx1 background

cellular

abnormal axon guidance ( J:110955 )

• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve

• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls

• phenotype of mice is more severe than in wild-type Lhx1 background

Genotype
MGI:5440833

cn3

• Allelic Composition: Ret^tm1Kln/Ret^tm1Kln; Slc6a3^tm1(cre)Xz/Slc6a3⁺
• Genetic Background: involves: 129S1/Sv

nervous system

loss of dopaminergic neurons ( J:188348 )

• late-onset, progressive

abnormal synaptic dopamine release ( J:188348 )

• deficits in elicited dopamine release