Phenotypes associated with this allele

• Allele Symbol: Gnpnat1^tm1Mak
• Allele Name: targeted mutation 1, Tak Mak
• Allele ID: MGI:3662646
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnpnat1^tm1Mak/Gnpnat1^tm1Mak	either: (involves: C57BL/6J) or (involves: CD-1)	MGI:3662893

Genotype
MGI:3662893

hm1

• Allelic Composition: Gnpnat1^tm1Mak/Gnpnat1^tm1Mak
• Genetic Background: either: (involves: C57BL/6J) or (involves: CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:111395 )

• homozygotes are present at E6.5 but die by E7.5; only empty yolk sacs, occasionally with a remnant of allantois, are found at E8.5 or E9.5

• no homozygotes are detected at E10.5-E12.5

embryo

embryonic growth retardation ( J:111395 )

• at E6.5, mutants resemble E5.5 wild-type embryos

absent mesoderm ( J:111395 )

abnormal extraembryonic tissue morphology ( J:111395 )

• exocoel is absent or corrupted in mutants at E7.5

small ectoplacental cone ( J:111395 )

• at E6.5, ~50% of mutants display a small ectoplacental cone

absent allantois ( J:111395 )

• absent or corrupted in mutants at E7.5

absent amnion ( J:111395 )

• absent or corrupted in mutants at E7.5

absent chorion ( J:111395 )

• absent or corrupted in mutants at E7.5

growth/size/body

embryonic growth retardation ( J:111395 )

• at E6.5, mutants resemble E5.5 wild-type embryos

cellular

decreased cell proliferation ( J:111395 )

• mutant erythroid bodies (EB) display only 24-79% of cellularity observed for wild-type ES cells in the absence of LIF