Phenotypes associated with this allele

• Allele Symbol: Arf6^tm1Yaka
• Allele Name: targeted mutation 1, Yasunori Kanaho
• Allele ID: MGI:3662650
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arf6^tm1Yaka/Arf6^tm1Yaka	involves: 129P2/OlaHsd * C57BL/6	MGI:3662882

Genotype
MGI:3662882

hm1

• Allelic Composition: Arf6^tm1Yaka/Arf6^tm1Yaka
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:111404 )

• lethality begins around E13.5 and continues through birth

perinatal lethality, incomplete penetrance ( J:111404 )

• lethality begins around E13.5 and continues through birth with almost all mice dead by P1

liver/biliary system

abnormal liver morphology ( J:111404 )

• at E13.5 livers appear sponge-like with a hypocellular structure especially in the peripheral regions

abnormal liver development ( J:111404 )

• at E9.0, primary hepatoblast expansion is similar to wild-type

• at E10.0, epithelial sheets fail to undergo elongation or form branching cord like structures and instead hepatoblasts remain clustered at the terminal edges of the epithelial sheets

• at E11.5 and E13.5 variable abnormal liver architecture with clusters of hepatocytes is seen

• at E13.5, but not at E10.0, increased apoptosis of hepatocytes and erythrocytes is seen in the liver

abnormal hepatic cord morphology ( J:111404 )

• at E10.0, epithelial sheets fail to undergo elongation or form branching cord like structures and instead hepatoblasts remain clustered at the terminal edges of the epithelial sheets

• hepatic cord formation is also impaired in cultures of fetal liver cells

decreased liver weight ( J:111404 )

• liver weight to body weight ratio is reduced to 2.9 +/- 0.7% compared to 5.2 +/-0.7% in wild-type mice; body weight is similar to wild-type

liver hypoplasia ( J:111404 )

• lobes are shriveled and hypoplastic; however the correct number of lobes are present and the number of proliferating cells seen at E13.5 is similar to wild-type

pale liver ( J:111404 )

• lobes appear thinner and paler

hematopoietic system

anemia ( J:111404 )

• occasional

cardiovascular system

hemorrhage ( J:111404 )

• occasional

homeostasis/metabolism

hydrops fetalis ( J:111404 )

• particularly in the head