All Phenotypes Mrtfa<tm1Eno> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrtfa^tm1Eno/Mrtfa^tm1Eno	involves: 129S/SvEv * C57BL/6	MGI:3713273
cn2	Mrtfa^tm1Eno/Mrtfa^tm1Eno Mrtfb^tm2.1Eno/Mrtfb^tm2.1Eno Tg(GFAP-cre)25Mes/0	involves: 129 * 129S/SvEv * C57BL/6 * FVB/N	MGI:4818692
cx3	Mamstr^tm1.2Eno/Mamstr^tm1.2Eno Mrtfa^tm1Eno/Mrtfa^tm1Eno	involves: 129 * C57BL/6	MGI:5313413

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:111412 )

• premature involution due to milk stasis

• light increase in proliferation during involution, resulting in post-involution mammary gland structure that is not significantly different from controls

abnormal mammary gland growth during lactation ( J:111412 )

• starting at day 4 of lactation, alveolar density is reduced and at day 12 alveoli are larger, less organized, and separated by adipocytes

• however, mammary development during embryogenesis and pregnancy are normal

• reduced numbers of myoepithelial cells are seen beginning at lactation day 4 and these cells are nearly absent at lactation day 12

• massive apoptosis of myoepithelial cells is detected at lactation day 10

abnormal mammary gland myoepithelium morphology ( J:111412 )

• reduced numbers of myoepithelial cells are seen beginning at lactation day 4 and these cells are nearly absent at lactation day 12

pale mammary gland ( J:111412 )

• mammary glands in lactating females at lactation day 12 are pale

abnormal lactation ( J:111412 )

• pups raised by homozygous females show growth retardation by P4 and lethality by P20 despite normal maternal nurturing behavior

• mammary glands in lactating females at lactation day 12 contain excess milk and are pale

galactostasis ( J:111412 )

• milk is trapped in the lumens of mammary glands, alveoli are dilated, and alveolar walls are thinner

abnormal mammary gland myoepithelium physiology ( J:111412 )

• massive apoptosis of myoepithelial cells is detected at lactation day 10

increased mammary gland apoptosis ( J:111412 )

• massive apoptosis of myoepithelial cells is detected at lactation day 10

integument

abnormal involution of the mammary gland ( J:111412 )

• premature involution due to milk stasis

• light increase in proliferation during involution, resulting in post-involution mammary gland structure that is not significantly different from controls

abnormal mammary gland growth during lactation ( J:111412 )

• starting at day 4 of lactation, alveolar density is reduced and at day 12 alveoli are larger, less organized, and separated by adipocytes

• however, mammary development during embryogenesis and pregnancy are normal

• reduced numbers of myoepithelial cells are seen beginning at lactation day 4 and these cells are nearly absent at lactation day 12

• massive apoptosis of myoepithelial cells is detected at lactation day 10

abnormal mammary gland myoepithelium morphology ( J:111412 )

• reduced numbers of myoepithelial cells are seen beginning at lactation day 4 and these cells are nearly absent at lactation day 12

pale mammary gland ( J:111412 )

• mammary glands in lactating females at lactation day 12 are pale

abnormal lactation ( J:111412 )

• pups raised by homozygous females show growth retardation by P4 and lethality by P20 despite normal maternal nurturing behavior

• mammary glands in lactating females at lactation day 12 contain excess milk and are pale

galactostasis ( J:111412 )

• milk is trapped in the lumens of mammary glands, alveoli are dilated, and alveolar walls are thinner

abnormal mammary gland myoepithelium physiology ( J:111412 )

• massive apoptosis of myoepithelial cells is detected at lactation day 10

increased mammary gland apoptosis ( J:111412 )

• massive apoptosis of myoepithelial cells is detected at lactation day 10

behavior/neurological

galactostasis ( J:111412 )

• milk is trapped in the lumens of mammary glands, alveoli are dilated, and alveolar walls are thinner

Allelic Composition	Mrtfa^tm1Eno/Mrtfa^tm1Eno Mrtfb^tm2.1Eno/Mrtfb^tm2.1Eno Tg(GFAP-cre)25Mes/0
Genetic Background	involves: 129 * 129S/SvEv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrtfa^tm1Eno mutation (0 available); any Mrtfa mutation (32 available)
Mrtfb^tm2.1Eno mutation (0 available); any Mrtfb mutation (68 available)
Tg(GFAP-cre)25Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:161853 )

• mice die between P16 and P21

nervous system

increased neuron apoptosis ( J:161853 )

• in the striatum

abnormal neuron differentiation ( J:161853 )

• neurons exhibit defective neurite outgrowth compared with wild-type neurons

abnormal neuronal migration ( J:161853 )

• neurons fail to migrate along the rostral migratory stream unlike in wild-type mice

absent corpus callosum ( J:161853 )

absent anterior commissure ( J:161853 )

decreased striatum size ( J:161853 )

• mice exhibit a smaller striatum than wild-type mice

abnormal hippocampus morphology ( J:161853 )

• the hippocampus is compressed unlike in wild-type mice

abnormal dentate gyrus morphology ( J:161853 )

abnormal hippocampus pyramidal cell layer ( J:161853 )

• poorly defined

abnormal hippocampus neuron morphology ( J:161853 )

• hippocampal neuronal projections are decreased compared to in wild-type mice

abnormal olfactory bulb morphology ( J:161853 )

• olfactory bulbs contain fewer neurons than in wild-type mice

abnormal rostral migratory stream morphology ( J:161853 )

• neurons fail to migrate along the rostral migratory stream unlike in wild-type mice

abnormal postnatal subventricular zone morphology ( J:161853 )

• mice exhibit an expansion of the subventricular zone compared with wild-type mice

• however, expansion is not do to increased cell proliferation

cellular

increased neuron apoptosis ( J:161853 )

• in the striatum

abnormal neuron differentiation ( J:161853 )

• neurons exhibit defective neurite outgrowth compared with wild-type neurons

impaired fibroblast cell migration ( J:161853 )

• mouse embryonic fibroblasts fail to migrate to the wound site in an in vitro scratch test unlike wild-type cells

abnormal neuronal migration ( J:161853 )

• neurons fail to migrate along the rostral migratory stream unlike in wild-type mice

growth/size/body

decreased body weight ( J:161853 )

• at P14

Allelic Composition	Mamstr^tm1.2Eno/Mamstr^tm1.2Eno Mrtfa^tm1Eno/Mrtfa^tm1Eno
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mamstr^tm1.2Eno mutation (0 available); any Mamstr mutation (21 available)
Mrtfa^tm1Eno mutation (0 available); any Mrtfa mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:179880 )

• about 40% die perinatally

muscle

decreased skeletal muscle weight ( J:179880 )

• in mice that survive past P1

muscular atrophy ( J:179880 )

• dramatic muscle wasting at 44 weeks of age

abnormal muscle physiology ( J:179880 )

• failure of satellite cell differentiation

abnormal skeletal muscle satellite cell proliferation ( J:179880 )

• hyperproliferative in culture

impaired skeletal muscle regeneration ( J:179880 )

• complete absence of myofiber regeneration at 7 days post cardiotoxin induced muscle injury

cellular

abnormal skeletal muscle satellite cell proliferation ( J:179880 )

• hyperproliferative in culture

growth/size/body

decreased body weight ( J:179880 )

• in mice that survive past P1

cachexia ( J:179880 )

• dramatic muscle wasting at 44 weeks of age

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