Phenotypes associated with this allele

• Allele Symbol: Del(7Gm7290-Th)1Lef
• Allele Name: deletion, Chr 7, Louis Lefebvre 1
• Allele ID: MGI:3662901
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(7Gm7290-Th)1Lef/Del(7Gm7290-Th)1Lef	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4366964
ht2	Del(7Gm7290-Th)1Lef/+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4366963

Genotype
MGI:4366964

hm1

• Allelic Composition: Del(7Gm7290-Th)1Lef/Del(7Gm7290-Th)1Lef
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:153719 )

• no mice are recovered at P0

• however, treatment with L-DOPA rescues perinatal/fetal lethality

postnatal lethality, complete penetrance ( J:153719 )

• while fewer mice treated with L-DOPA are found at P0 all mice die prior to weaning

growth/size/body

decreased body weight ( J:153719 )

• in mice treated with L-DOPA

cardiovascular system

abnormal cardiovascular development ( J:153719 )

• at E10.5 to E14.5

Genotype
MGI:4366963

ht2

• Allelic Composition: Del(7Gm7290-Th)1Lef/+
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

growth/size/body

decreased birth weight ( J:153719 )

• when the deletion is inherited maternally, mice exhibit a 20% reduction in birth weight compared to wild-type mice

• however, mice exhibit normal birth weight when the deletion is inherited paternally

• treatment with L-DOPA does not restore birth weight when the deletion is inherited maternally

decreased body weight ( J:153719 )

• when the deletion is inherited maternally

abnormal prenatal growth/weight/body size ( J:153719 )

• when the deletion is inherited maternally, mice exhibit decreased intrauterine growth compared with wild-type mice