Phenotypes associated with this allele

• Allele Symbol: Ret^tm1.1Kln
• Allele Name: targeted mutation 1.1, Rudiger Klein
• Allele ID: MGI:3662902
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ret^tm1.1Kln/Ret^tm1.1Kln	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J	MGI:3662905
cx2	Lhx1^tm1Tmj/Lhx1^+ Ret^tm1.1Kln/Ret^tm1.1Kln	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J	MGI:3662907
cx3	Epha4^Gt(PST038)Byg/Epha4^Gt(PST038)Byg Ret^tm1.1Kln/Ret^tm1.1Kln	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J	MGI:3662909

Genotype
MGI:3662905

hm1

• Allelic Composition: Ret^tm1.1Kln/Ret^tm1.1Kln
• Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal innervation pattern to muscle ( J:110955 )

• at E11.5 in nulls, the developing ventral branch of axons coming from the sciatic plexus appear thicker while the dorsal branch is reduced; most embryos displayed defects categorized as intermediate reductions (Category II: intermediate reductions)

• at E12.5 the branchpoint of peroneal nerve (PN) seen in wild-type is absent or has become the most distal extension of the peroneal nerve which is also reduced in diameter; in most severe cases, nerve is almost completely absent

• mutants have peroneal nerves of reduced length (~40% of control) at E11.5

Genotype
MGI:3662907

cx2

• Allelic Composition: Lhx1^tm1Tmj/Lhx1⁺; Ret^tm1.1Kln/Ret^tm1.1Kln
• Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * CBA/J

nervous system

abnormal axon guidance ( J:110955 )

• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve

• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls

cellular

abnormal axon guidance ( J:110955 )

• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve

• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls

Genotype
MGI:3662909

cx3

• Allelic Composition: Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg}; Ret^tm1.1Kln/Ret^tm1.1Kln
• Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * CBA/J

nervous system

abnormal axon guidance ( J:110955 )

• mice show severe axon guidance defects

• all embryos have severely affected, Category III phenotypes; peroneal nerve is severely shortened and often defasciculated

abnormal innervation pattern to muscle ( J:110955 )

cellular

abnormal axon guidance ( J:110955 )

• mice show severe axon guidance defects

• all embryos have severely affected, Category III phenotypes; peroneal nerve is severely shortened and often defasciculated