Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Ins2-Fas*I246N)1Ach transgene insertion 1, Alexander V Chervonsky MGI:3662920 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double transgenics show slower onset of diabetes compared to NOD-Tg(Ins2-Fasl)24Ach single transgenics
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 1 diabetes mellitus | DOID:9744 |
OMIM:222100 |
J:81416 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• transgenic mice show some level of protection against spontaneous diabetes, correlating with level of transgene expression
• onset of diabetes in slightly delayed in mice injected with diabetic T cells compared to NOD controls (16 days vs 13 days) or Fasl transgenic mice (16 days vs 5 days)
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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