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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc6a4tm1(cre)Grch
targeted mutation 1, Jay A Gingrich
MGI:3663166
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Htr2atm1Grch/Htr2atm2Grch
Slc6a4tm1(cre)Grch/Slc6a4+ 		involves: 129S6/SvEvTac MGI:3663444


Genotype
MGI:3663444
cn1
Allelic
Composition		 Htr2atm1Grch/Htr2atm2Grch
Slc6a4tm1(cre)Grch/Slc6a4+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2atm1Grch mutation (0 available); any Htr2a mutation (43 available)
Htr2atm2Grch mutation (0 available); any Htr2a mutation (43 available)
Slc6a4tm1(cre)Grch mutation (0 available); any Slc6a4 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal anxiety-related response ( J:110958 )
• reduced inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors in the dark-light choice test
• selective restoration of 5HT2AR signaling to the thalamus did not normalized conflict anxiety behaviors




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory