Phenotypes associated with this allele

• Allele Symbol: Ptprg^tm1Shar
• Allele Name: targeted mutation 1, Sheila Harroch
• Allele ID: MGI:3663183
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprg^tm1Shar/Ptprg^tm1Shar	involves: 129S6/SvEvTac * C57BL/6	MGI:3663266

Genotype
MGI:3663266

hm1

• Allelic Composition: Ptprg^tm1Shar/Ptprg^tm1Shar
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:110322 )

N • working memory and contextual fear responses are comparable to conrols; null mice do not show altered susceptibility to pharmacologically-induced seizures

abnormal cued conditioning behavior ( J:110322 )

• mice show reduced performance in cued fear conditioning tests

abnormal fear/anxiety-related behavior ( J:110322 )

• in tail-suspension test, mutants show a longer latency to first immobilization; however, total immobility times are comparable to controls

hyperresponsive to tactile stimuli ( J:110322 )

• null mice display reduced latencies vs wild-type in a tail flick test, but have normal pain and shock thresholds

decreased startle reflex ( J:110322 )

• mutants show improved pre-pulse inhibition compared to wild-type in an auditory stimulus test

impaired coordination ( J:110322 )

• null mice show significant motor deficits as assessed by the rotarod and hanging wire tests, although muscle strength is comparable to wild-type