Phenotypes associated with this allele

• Allele Symbol: Timp4^tm1Vuo
• Allele Name: targeted mutation 1, Eero Vuorio
• Allele ID: MGI:3663251
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timp4^tm1Vuo/Timp4^tm1Vuo	involves: 129S7/SvEvBrd * C57BL/6	MGI:3687378
cx2	Mmp2^tm1Ito/Mmp2^tm1Ito Timp4^tm1Vuo/Timp4^tm1Vuo	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:4839035

Genotype
MGI:3687378

hm1

• Allelic Composition: Timp4^tm1Vuo/Timp4^tm1Vuo
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cardiac rupture, decreased collagen synthesis, and disruption of collagen network in Timp4^tm1Vuo/Timp4^tm1Vuo hearts after myocardial infarction

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:165901 )

• following induction of myocardial infarction (left anterior descending coronary artery), mice exhibit increased mortality due to left ventricle rupture compared to in similarly treated wild-type mice

cardiovascular system

increased heart left ventricle weight ( J:165901 )

• in aged mice

abnormal heart right ventricle morphology ( J:165901 )

• aged mice exhibit increased septal and posterior wall thickness compared to in wild-type mice

decreased coronary flow rate ( J:165901 )

• aged mice exhibit decreased coronary flow reserve compared with wild-type mice

abnormal myocardial fiber physiology ( J:165901 )

• aged mice exhibit poor myocardial performance index compared with wild-type mice

• however, fractional shortening is normal

abnormal response to cardiac infarction ( J:165901 )

• following induction of myocardial infarction (left anterior descending coronary artery ligation; LDA), mice exhibit increased mortality due to left ventricle rupture, compromised cardiac collagen network, and increased neutrophil accumulation compared to in similarly treated wild-type mice

• however, mice that survive myocardial infarction exhibit normal deterioration of heart function

homeostasis/metabolism

abnormal response to cardiac infarction ( J:165901 )

• following induction of myocardial infarction (left anterior descending coronary artery ligation; LDA), mice exhibit increased mortality due to left ventricle rupture, compromised cardiac collagen network, and increased neutrophil accumulation compared to in similarly treated wild-type mice

• however, mice that survive myocardial infarction exhibit normal deterioration of heart function

Genotype
MGI:4839035

cx2

• Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito; Timp4^tm1Vuo/Timp4^tm1Vuo
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Cardiac neutrophil accumulation post-myocardial infraction is normalized in Timp4^tm1Vuo/Timp4^tm1Vuo Mmp2^tm1Ito/Mmp2^tm1Ito mice

cardiovascular system

cardiovascular system phenotype ( J:165901 )

N • mice exhibit normal mortality and neutrophil accumulation following left anterior descending coronary artery ligation