All Phenotypes Tasp1<tm1.1Jjdh> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tasp1^tm1.1Jjdh/Tasp1^tm1.1Jjdh	B6.129X1-Tasp1^tm1.1Jjdh	MGI:5548114
hm2	Tasp1^tm1.1Jjdh/Tasp1^tm1.1Jjdh	involves: 129X1/SvJ	MGI:3687260
hm3	Tasp1^tm1.1Jjdh/Tasp1^tm1.1Jjdh	involves: 129X1/SvJ * C57BL/6	MGI:5565089

Allelic Composition	Tasp1^tm1.1Jjdh/Tasp1^tm1.1Jjdh
Genetic Background	B6.129X1-Tasp1^tm1.1Jjdh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tasp1^tm1.1Jjdh mutation (1 available); any Tasp1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

glossopharyngeal nerve hypoplasia ( J:201612 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:112159 )

• most die during day 1 or day 2 postnatally

• only about 13% survive to weaning

prenatal lethality, incomplete penetrance ( J:112159 )

• only about 89% of expected homozygotes are born

behavior/neurological

abnormal suckling behavior ( J:112159 )

• no indication that pups dying within the first 2 days of life ever suckle

growth/size/body

decreased embryo size ( J:112159 )

• first noticeable at E14.5

• significantly smaller than normal at E18.5

decreased body size ( J:112159 )

• markedly smaller than normal immediately after birth

skeleton

abnormal sternebra morphology ( J:112159 )

• incomplete segmentation between sternebrae 3 and 4

increased rib number ( J:112159 )

• 14 pairs of ribs; additional pair of sternal ribs

abnormal vertebrae morphology ( J:112159 )

abnormal cervical vertebrae morphology ( J:112159 )

abnormal arcus anterior morphology ( J:112159 )

• anterior arch of the atlas is broadened and tilted anteriorly

abnormal cervical axis morphology ( J:112159 )

• split neural arch of the axis

vertebral transformation ( J:112159 )

thoracic vertebral transformation ( J:112159 )

• anterior transformation of T8 to T7 with resulting additional sternal ribs

cervical vertebral transformation ( J:112159 )

• posterior transformation of C7 to T1 with attached aberrant ribs

lumbar vertebral transformation ( J:112159 )

• anterior transformation of L1 to T13

cellular

decreased cell proliferation ( J:112159 )

• delayed entry of embryonic fibroblasts into the S phase of the cell cycle

embryo

decreased embryo size ( J:112159 )

• first noticeable at E14.5

• significantly smaller than normal at E18.5

Allelic Composition	Tasp1^tm1.1Jjdh/Tasp1^tm1.1Jjdh
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tasp1^tm1.1Jjdh mutation (1 available); any Tasp1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:205038 )

N	• females are fertile

azoospermia ( J:205038 )

• absence of mature spermatozoa in the epididymis

abnormal spermatid morphology ( J:205038 )

• severely decreased number of elongated spermatids

• decrease in spermatid numbers is detected at 4 weeks of age during the first wave of spermatogenesis

increased male germ cell apoptosis ( J:205038 )

• increase in apoptosis in the seminiferous tubules

small seminiferous tubules ( J:205038 )

• approximately a 33% reduction in diameter

• fewer germ cell layers are present

seminiferous tubule degeneration ( J:205038 )

• at 5 weeks of age

decreased testis weight ( J:205038 )

• about a 50% reduction in weight compared to wild-type littermates

arrest of spermiogenesis ( J:205038 )

• most round spermatids fail to advance beyond step 11 of spermiogenesis

male infertility ( J:205038 )

• surviving males are infertile

endocrine/exocrine glands