Phenotypes associated with this allele

• Allele Symbol: Map4k5^tm1Jhk
• Allele Name: targeted mutation 1, John H Kehrl
• Allele ID: MGI:3663310
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map4k5^tm1Jhk/Map4k5^tm1Jhk	either: B6.129-Map4k5^tm1Jhk or (involves: 129 * C57BL/6)	MGI:3664260

Genotype
MGI:3664260

hm1

• Allelic Composition: Map4k5^tm1Jhk/Map4k5^tm1Jhk
• Genetic Background: either: B6.129-Map4k5^tm1Jhk or (involves: 129 * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:112134 )

• Wnt signaling results in decreased levels of cytosolic beta-catenin in mutant progenitor B cells

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:112134 )

• progenitor B cells from mutants show significant defects, including a delay and suboptimal response, in Wnt-mediated JNK activation compared to wild-type B cells

• in cells from mutants, Wnt induces serine 9 phosphorylation of Gsk3b in progenitor B cells poorly compared to wild-type progenitor B cells