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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Igfbp5tm1Jep
targeted mutation 1, John E Pintar
MGI:3663363
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Igfbp5tm1Jep/Igfbp5tm1Jep involves: 129S/SvEv * C57BL/6J MGI:3664118
cx2
Igfbp3tm1Jep/Igfbp3tm1Jep
Igfbp4tm1Jep/Igfbp4tm1Jep
Igfbp5tm1Jep/Igfbp5tm1Jep
involves: 129S/SvEv * C57BL/6J MGI:3664121


Genotype
MGI:3664118
hm1
Allelic
Composition
Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igfbp5tm1Jep mutation (0 available); any Igfbp5 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• body weights of male and female mutants are indistinguishable from controls from birth to 42 days of age




Genotype
MGI:3664121
cx2
Allelic
Composition
Igfbp3tm1Jep/Igfbp3tm1Jep
Igfbp4tm1Jep/Igfbp4tm1Jep
Igfbp5tm1Jep/Igfbp5tm1Jep
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igfbp3tm1Jep mutation (1 available); any Igfbp3 mutation (21 available)
Igfbp4tm1Jep mutation (0 available); any Igfbp4 mutation (13 available)
Igfbp5tm1Jep mutation (0 available); any Igfbp5 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice exhibit significantly greater growth retardation than Igfbp4-null mice becoming significant at P20 (78% of normal weight) and continues through week 14

homeostasis/metabolism
• mutants have a 50% reduction in total serum Igf-1 compared to wild-type; Igf-1 bioactivity is significantly suppressed in mutants
• mutants show lower circulating Igf-1 levels than wild-type controls at all time points examined after glucose challenge; percentage increase in Igf-1 levels after challenge is significantly higher in mutants compared to wild-type at 30 minutes (43%) while wild-type only show a 6% increase at 30 minutes and 8% at 60 minutes
• after an overnight fast, mutants have significantly reduced glucose levels vs wild-type mice
• mice show enhanced insulin secretion after glucose challenge
• mutants show significantly decreased glucose levels after glucose challenge (from 30-120 minutes) compared to wild-type or Igfbp3 or Igfbp5 mutants; decrease is significantly enhanced compared to Igfbp4 mutants
• after an overnight fast, mutants have significantly reduced glucose levels vs wild-type mice
• mutants show increased circulating insulin levels after glucose challenge that are significantly higher than the increase seen in wild-type after glucose challenge
• mutants show slightly increased AKT activation levels and significantly decreased Erk/MAPK (72% decreased) activation levels vs wild-type

endocrine/exocrine glands
• islets in mutants have increased area; beta-cell area is increased ~37% compared to wild-type
• mice show enhanced insulin secretion after glucose challenge

adipose tissue
• pads of mutants contain much smaller adipocytes than in wild-type fat pads
• weights of all fat pads are significantly decreased in mutants

muscle
• quadriceps muscle is decreased in weight compared to controls

limbs/digits/tail
• quadriceps muscle is decreased in weight compared to controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory