Phenotypes associated with this allele

• Allele Symbol: Gpr12^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3663376
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr12^tm1Dgen/Gpr12^tm1Dgen	B6.129P2-Gpr12^tm1Dgen	MGI:3664276

Genotype
MGI:3664276

hm1

• Allelic Composition: Gpr12^tm1Dgen/Gpr12^tm1Dgen
• Genetic Background: B6.129P2-Gpr12^tm1Dgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:111942 )

• increased by 10% and 11% at 5 and 11 weeks of age, respectively; however, no difference in absolute food intake is detected

obese ( J:111942 )

increased liver weight ( J:111942 )

• 18% and 17% increase in absolute and relative (compared to brain weight) liver weight

adipose tissue

increased gonadal fat pad weight ( J:111942 )

• 56% and 55% increase in absolute and relative (compared to brain weight) white fat

increased retroperitoneal fat pad weight ( J:111942 )

• 101% and 99% increase in absolute and relative (compared to brain weight) white fat

increased percent body fat/body weight ( J:111942 )

• 28% increase in the absolute amount of fat per mouse

homeostasis/metabolism

increased circulating glucose level ( J:111942 )

• 21% increase in non-fasting serum glucose levels but no significant change in serum insulin levels

abnormal energy expenditure ( J:111942 )

• decreased energy expenditure

decreased respiratory quotient ( J:111942 )

• decrease in the respiratory exchange ratio

abnormal cholesterol homeostasis ( J:111942 )

increased circulating cholesterol level ( J:111942 )

• 25% increase with increased HDL and LDL but not VLDL levels

increased circulating HDL cholesterol level ( J:111942 )

increased circulating LDL cholesterol level ( J:111942 )

increased liver triglyceride level ( J:111942 )

• increase in hepatic triglyceride content

behavior/neurological

behavior/neurological phenotype ( J:111942 )

N • despite differences in energy expenditure and body weight, no significant differences are seen in food or water intake or in activity level

liver/biliary system

increased liver weight ( J:111942 )

• 18% and 17% increase in absolute and relative (compared to brain weight) liver weight

increased liver triglyceride level ( J:111942 )

• increase in hepatic triglyceride content

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:111942