mortality/aging
• embryos exhibit a lethal phenotype associated with head development
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embryo
• homozygotes phenocopy Ssbp3Tg(SOD1)1Hssk homozygotes
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growth/size/body
• homozygotes lack bones anterior to the parietal bone
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• homozygotes phenocopy Ssbp3Tg(SOD1)1Hssk homozygotes
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nervous system
• homozygotes phenocopy Ssbp3Tg(SOD1)1Hssk homozygotes
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• midbrain is deleted or truncated
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• midbrain is deleted or truncated
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• forebrain is deleted
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craniofacial
• mutants display a severe anterior truncation
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skeleton
• homozygotes phenocopy Ssbp3Tg(SOD1)1Hssk homozygotes
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• mutants display a severe anterior truncation
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