Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-TEAD4)2Afrs
• Allele Name: transgene insertion 2, Alexandre F R Stewart
• Allele ID: MGI:3663410
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-TEAD4)2Afrs/0	involves: FVB	MGI:3663750

Genotype
MGI:3663750

tg1

• Allelic Composition: Tg(Myh6-TEAD4)2Afrs/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:112740 )

• sudden death is less frequent than in line 3 (Tg(Myh6-TEAD4)3Afrs)

cardiovascular system

dilated heart atrium ( J:112740 )

• atrial enlargment develops more slowly than in line 3 (Tg(Myh6-TEAD4)3Afrs)

atrial fibrillation ( J:112740 )

• burst pacing from an intracardiac catheter electrode produced transient episodes of atrial flutter/fibrillation in 6.5 month old mutants

abnormal impulse conducting system conduction ( J:112740 )

• exhibit slower conduction over the surface of the atrial and ventricular myocardium

• significant prolongation of the AH interval but not the HV interval, suggesting a conduction delay above the bundle of His

• conduction defects are correlated with dephosphorylation of Gja5 (connexin40) and Gja1 (connexin43) and upregulation of protein phosphatase 1 beta, suggesting that defective conduction is a result of impaired gap-junction conductance rather than assembly

prolonged PR interval ( J:112740 )

• surface and intracardiac ECGs reveal prolongation of the PR interval

prolonged QRS complex duration ( J:112740 )

• surface and intracardiac ECGs reveal prolongation of QRS duration