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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igk-Jtm1Cog
targeted mutation 1, Michel Cogne
MGI:3663520
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igk-Jtm1Cog/Igk-Jtm1Cog involves: 129P2/OlaHsd * C57BL/6 MGI:3663765
ht2
 		Igk-Jtm1Cog/Igk-Jtm1.1Cog involves: 129P2/OlaHsd * C57BL/6 MGI:3663766


Genotype
MGI:3663765
hm1
Allelic
Composition		 Igk-Jtm1Cog/Igk-Jtm1Cog
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk-Jtm1Cog mutation (0 available); any Igk-J mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:110100 )
• peripheral B cell compartment in homozygotes is reduced with B cells accounting for ~25% of total splenocytes compared to 40% in wild-type
• a significant increase in lambda+ B cells is observed while 10% of B cells express both kappa and lambda light chains
• in kappa/lambda light chain included-B cells in mutant mice, a strong increase of CD23low/CD21high (marginal zone, MZ) B cells is observed compared to wild-type; ~15% of kappa-gated and 40% of kappa/lambda-included B cells are in the MZ compartment in mutants contrasting with the 5% of MZ B cells in wild-type
• B1 cells are unaffected in transgenic animals
abnormal B cell physiology ( J:110100 )
• B cell receptor associated kappa chain expression is of lower density than endogenous kappa light chain expression in B cells
• a 9-fold increase in kappa expression is seen in lambda B cells vs wild-type

hematopoietic system
decreased B cell number ( J:110100 )
• peripheral B cell compartment in homozygotes is reduced with B cells accounting for ~25% of total splenocytes compared to 40% in wild-type
• a significant increase in lambda+ B cells is observed while 10% of B cells express both kappa and lambda light chains
• in kappa/lambda light chain included-B cells in mutant mice, a strong increase of CD23low/CD21high (marginal zone, MZ) B cells is observed compared to wild-type; ~15% of kappa-gated and 40% of kappa/lambda-included B cells are in the MZ compartment in mutants contrasting with the 5% of MZ B cells in wild-type
• B1 cells are unaffected in transgenic animals
abnormal B cell physiology ( J:110100 )
• B cell receptor associated kappa chain expression is of lower density than endogenous kappa light chain expression in B cells
• a 9-fold increase in kappa expression is seen in lambda B cells vs wild-type




Genotype
MGI:3663766
ht2
Allelic
Composition		 Igk-Jtm1Cog/Igk-Jtm1.1Cog
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk-Jtm1.1Cog mutation (0 available); any Igk-J mutation (11 available)
Igk-Jtm1Cog mutation (0 available); any Igk-J mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:110100 )
N
• no autoantibodies are detected in the sera of transgenic animals
abnormal B cell number ( J:110100 )
• a significant increase in lambda+ B cells is observed while 25% of B cells express both kappa and lambda light chains
• B1 cells are unaffected in transgenic animals
increased plasma cell number ( J:110100 )
• there are increased numbers of kappa-lambda hybrid Ig molecules and lambda-containing Ig molecules vs wild-type
decreased B cell number ( J:110100 )
• mice show significant reduction in peripheral B cell number with only ~20% of total splenocytes being B cells
increased pre-B cell number ( J:110100 )
• number of B220+/CD43+ pre-B cells is slightly increased
decreased naive B cell number ( J:110100 )
• total B220+/IgD+ recirculating B cells (naive, mature B cells) are decreased ~2-fold
abnormal plasma cell morphology ( J:110100 )
• about 25% of plasma cells appear to produce simultaneously both light chain types even if the proportion of lambda-only plasma cells are observed

hematopoietic system
abnormal B cell number ( J:110100 )
• a significant increase in lambda+ B cells is observed while 25% of B cells express both kappa and lambda light chains
• B1 cells are unaffected in transgenic animals
increased plasma cell number ( J:110100 )
• there are increased numbers of kappa-lambda hybrid Ig molecules and lambda-containing Ig molecules vs wild-type
decreased B cell number ( J:110100 )
• mice show significant reduction in peripheral B cell number with only ~20% of total splenocytes being B cells
increased pre-B cell number ( J:110100 )
• number of B220+/CD43+ pre-B cells is slightly increased
decreased naive B cell number ( J:110100 )
• total B220+/IgD+ recirculating B cells (naive, mature B cells) are decreased ~2-fold
abnormal plasma cell morphology ( J:110100 )
• about 25% of plasma cells appear to produce simultaneously both light chain types even if the proportion of lambda-only plasma cells are observed




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11/12/2024
MGI 6.24 		The Jackson Laboratory