Phenotypes associated with this allele

• Allele Symbol: Igk-J^tm1.1Cog
• Allele Name: targeted mutation 1.1, Michel Cogne
• Allele ID: MGI:3663521
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igk-J^tm1Cog/Igk-J^tm1.1Cog	involves: 129P2/OlaHsd * C57BL/6	MGI:3663766

Genotype
MGI:3663766

ht1

• Allelic Composition: Igk-J^tm1Cog/Igk-J^tm1.1Cog
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:110100 )

N • no autoantibodies are detected in the sera of transgenic animals

abnormal B cell number ( J:110100 )

• a significant increase in lambda+ B cells is observed while 25% of B cells express both kappa and lambda light chains

• B1 cells are unaffected in transgenic animals

increased plasma cell number ( J:110100 )

• there are increased numbers of kappa-lambda hybrid Ig molecules and lambda-containing Ig molecules vs wild-type

decreased B cell number ( J:110100 )

• mice show significant reduction in peripheral B cell number with only ~20% of total splenocytes being B cells

increased pre-B cell number ( J:110100 )

• number of B220+/CD43+ pre-B cells is slightly increased

decreased naive B cell number ( J:110100 )

• total B220+/IgD+ recirculating B cells (naive, mature B cells) are decreased ~2-fold

abnormal plasma cell morphology ( J:110100 )

• about 25% of plasma cells appear to produce simultaneously both light chain types even if the proportion of lambda-only plasma cells are observed

hematopoietic system

abnormal B cell number ( J:110100 )

• a significant increase in lambda+ B cells is observed while 25% of B cells express both kappa and lambda light chains

• B1 cells are unaffected in transgenic animals

increased plasma cell number ( J:110100 )

• there are increased numbers of kappa-lambda hybrid Ig molecules and lambda-containing Ig molecules vs wild-type

decreased B cell number ( J:110100 )

• mice show significant reduction in peripheral B cell number with only ~20% of total splenocytes being B cells

increased pre-B cell number ( J:110100 )

• number of B220+/CD43+ pre-B cells is slightly increased

decreased naive B cell number ( J:110100 )

• total B220+/IgD+ recirculating B cells (naive, mature B cells) are decreased ~2-fold

abnormal plasma cell morphology ( J:110100 )

• about 25% of plasma cells appear to produce simultaneously both light chain types even if the proportion of lambda-only plasma cells are observed