Phenotypes associated with this allele

• Allele Symbol: Bahcc1^tm1Mnkm
• Allele Name: targeted mutation 1, Manabu Nakayama
• Allele ID: MGI:3663684
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bahcc1^tm1Mnkm/Bahcc1^tm1Mnkm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3686901

Genotype
MGI:3686901

hm1

• Allelic Composition: Bahcc1^tm1Mnkm/Bahcc1^tm1Mnkm
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:111319 )

• majority die shortly after birth, between P0 and P2

behavior/neurological

abnormal gait ( J:111319 )

• one homozygote that survives to adulthood shows difficulty walking, often dragging the hind legs, indicating hind leg motor dysfunction

decreased locomotor activity ( J:111319 )

• travel shorter distances and cover only part of field in an open field

bradykinesia ( J:111319 )

• homozygotes are much less active than controls when placed into novel home cages