Phenotypes associated with this allele

• Allele Symbol: Adipoq^tm1Far
• Allele Name: targeted mutation 1, Bob Farese
• Allele ID: MGI:3663753
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adipoq^tm1Far/Adipoq^tm1Far	involves: 129S4/SvJae * C57BL/6J	MGI:3664725
hm2	Adipoq^tm1Far/Adipoq^tm1Far	involves: C57BL/6J	MGI:3664724
cx3	Adipoq^tm1Far/Adipoq^tm1Far Dgat1^tm1Far/Dgat1^tm1Far	involves: 129S4/SvJae * C57BL/6J	MGI:3664726

Genotype
MGI:3664725

hm1

• Allelic Composition: Adipoq^tm1Far/Adipoq^tm1Far
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:111346 )

• when Dgat1-suffficient, Adipoq-deficient mice are weaned onto a high-fat diet, they show increased body weight over 20 weeks vs wild-type controls

homeostasis/metabolism

increased circulating glucose level ( J:111346 )

• after high-fat diet for 8 weeks, mice have increased blood glucose after an overnight fast vs controls

impaired glucose tolerance ( J:111346 )

• after glucose challenge, impaired glucose tolerance compared to wild-type controls is seen: Adipoq deficiency impairs glucose tolerance by ~25%

increased liver triglyceride level ( J:111346 )

• after receiving a high-fat diet for 20 weeks, hepatic triglyceride levels are significantly increased vs controls

liver/biliary system

increased liver triglyceride level ( J:111346 )

• after receiving a high-fat diet for 20 weeks, hepatic triglyceride levels are significantly increased vs controls

increased susceptibility to diet-induced hepatic steatosis ( J:111346 )

• when fed a high fat diet for 20 weeks, mice display hepatic steatosis, which is higher than in wild-type controls

adipose tissue

increased total body fat amount ( J:111346 )

• slightly higher than wild-type mice, but not significant

increased percent body fat/body weight ( J:111346 )

• slightly higher than wild-type mice, but not significant

Genotype
MGI:3664724

hm2

• Allelic Composition: Adipoq^tm1Far/Adipoq^tm1Far
• Genetic Background: involves: C57BL/6J

homeostasis/metabolism

impaired glucose tolerance ( J:111346 )

• male mutants fed a normal chow diet show similar glucose tolerance to wild-type at 3 months of age; when male mutants and conrols are fed a high-fat diet for 15 weeks, they show greater impairment of glucose tolerance than wild-type mice

• females show no impairment of glucose tolerance on normal chow or high-fat diets

Genotype
MGI:3664726

cx3

• Allelic Composition: Adipoq^tm1Far/Adipoq^tm1Far; Dgat1^tm1Far/Dgat1^tm1Far
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

adipose tissue

decreased total body fat amount ( J:111346 )

• lower than Dgat1-sufficient mice

decreased percent body fat/body weight ( J:111346 )

• lower than Dgat1-sufficient mice

behavior/neurological

increased food intake ( J:111346 )

• mice show significant increase in food intake compared to other genotypes

endocrine/exocrine glands

abnormal lactation ( J:111346 )

♀ • females display a lactation defect similar to Dgat1-deficient mice

growth/size/body

decreased body weight ( J:111346 )

• when Dgat1-deficient, Adipoq-deficient mice are weaned onto a high-fat diet, they show decreased body weight over 20 weeks similar to Dgat1-deficient, Adipoq-sufficient mice

homeostasis/metabolism

decreased circulating glucose level ( J:111346 )

• after high-fat diet for 8 weeks, mice are completely protected from diet-induced fasting increases in blood glucose after an overnight fast; levels are similar to Dgat1-deficient mice

decreased circulating leptin level ( J:111346 )

• serum leptin levels are significantly lower than in Dgat1-sufficient animals regardless of Adipoq genotype (2.5 ng/ml vs ~17.7 ng/ml in Dgat1-suffcient)

increased oxygen consumption ( J:111346 )

• mice fed a higher fat diet have higher levels of oxygen consumption than Dgat1-sufficient mice

abnormal glucose tolerance ( J:111346 )

• after glucose challenge, mice show improved glucose tolerance compared to Adipoq-deficient mice but slightly more impaired tolerance than Dgat1-deficient mice; Dgat1-deficiency improves glucose tolerance by ~30-35% vs controls while Adipoq deficiency impairs glucose tolerance by ~25%

decreased liver cholesterol level ( J:111346 )

• after receiving a high-fat diet for 20 weeks, hepatic cholesterol ester levels are markedly reduced vs controls

decreased liver triglyceride level ( J:111346 )

• after receiving a high-fat diet for 20 weeks, hepatic triglyceride levels are markedly reduced vs controls

liver/biliary system

decreased liver cholesterol level ( J:111346 )

• after receiving a high-fat diet for 20 weeks, hepatic cholesterol ester levels are markedly reduced vs controls

decreased liver triglyceride level ( J:111346 )

• after receiving a high-fat diet for 20 weeks, hepatic triglyceride levels are markedly reduced vs controls

decreased susceptibility to diet-induced hepatic steatosis ( J:111346 )

• when fed a high fat diet for 20 weeks, mice show significantly less hepatic steatosis vs wild-type controls

integument

abnormal lactation ( J:111346 )

♀ • females display a lactation defect similar to Dgat1-deficient mice

abnormal coat appearance ( J:111346 )

• double mutants have dry fur similar to Dgat1-deficient mice

premature hair loss ( J:111346 )

• similar to Dgat1-deficient mice