Phenotypes associated with this allele

• Allele Symbol: Htt^tm4Szi
• Allele Name: targeted mutation 4, Scott Zeitlin
• Allele ID: MGI:3663763
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Htt^tm4Szi/Htt^tm4Szi	involves: 129S1/Sv	MGI:3664660
ht2	Htt^tm4Szi/Htt^tm5Szi	involves: 129S1/Sv	MGI:3664661
cn3	Htt^tm4Szi/Htt^tm5Szi Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3664662
cn4	Htt^tm4Szi/Htt^tm4Szi Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3664663

Genotype
MGI:3664660

hm1

• Allelic Composition: Htt^tm4Szi/Htt^tm4Szi
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:111323 )

• conditional mice lacking Hdh are fertile, have normal life spans and are indistinguishable from wild-type littermates

Genotype
MGI:3664661

ht2

• Allelic Composition: Htt^tm4Szi/Htt^tm5Szi
• Genetic Background: involves: 129S1/Sv

normal phenotype

no abnormal phenotype detected ( J:111323 )

• conditional mice lacking Hdh are fertile, have normal life spans and are indistinguishable from wild-type littermates

Genotype
MGI:3664662

cn3

• Allelic Composition: Htt^tm4Szi/Htt^tm5Szi; Tg(Hsp70-1-cre)1Arge/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type; embryonic portion of conceptus is small and stubby with no obvious head folds and somites are absent

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

embryo

embryonic growth retardation ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

abnormal embryonic tissue morphology ( J:111323 )

• embryonic portion of conceptus is small and stubby with no obvious head folds

absent somites ( J:111323 )

• at E8.5

growth/size/body

embryonic growth retardation ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

Genotype
MGI:3664663

cn4

• Allelic Composition: Htt^tm4Szi/Htt^tm4Szi; Tg(Hsp70-1-cre)1Arge/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type; embryonic portion of conceptus is small and stubby with no obvious head folds and somites are absent

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

embryo

embryonic growth retardation ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

abnormal embryonic tissue morphology ( J:111323 )

• embryonic portion of conceptus is small and stubby with no obvious head folds

absent somites ( J:111323 )

• at E8.5

growth/size/body

embryonic growth retardation ( J:111323 )

• E8.5 embryos are developmentally retarded in appearance compared to wild-type

• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed