All Phenotypes Tg(Scgb1a1-cre)1Grau MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Scgb1a1-cre)1Grau
transgene insertion 1, Timothy A Graubert
MGI:3663797

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nfe2l2^tm1.1Sred/Nfe2l2^tm1.1Sred Tg(Scgb1a1-cre)1Grau/0	involves: C57BL/6 * C57BL/6J	MGI:5463906
cn2	Keap1^tm1.1Sbis/Keap1^tm1.1Sbis Tg(Scgb1a1-cre)1Grau/0	involves: C57BL/6J	MGI:4948839

Allelic Composition	Nfe2l2^tm1.1Sred/Nfe2l2^tm1.1Sred Tg(Scgb1a1-cre)1Grau/0
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2l2^tm1.1Sred mutation (2 available); any Nfe2l2 mutation (90 available)
Tg(Scgb1a1-cre)1Grau mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-1 beta secretion ( J:191916 )

• 2-fold in the bronchoalveolar lavage fluid under normal conditions

decreased tumor necrosis factor secretion ( J:191916 )

• in the bronchoalveolar lavage fluid under hypoxic conditions

homeostasis/metabolism

increased susceptibility to injury ( J:191916 )

• mice exhibit higher levels of hyperoxic lung injury with increased protein and cells (macrophage and epithelial cells) in the bronchoalveolar lavage fluid and increased cell death in lung parenchyma compared with control mice

• 72 hours after oxidant exposure, mice exhibit persistent cellular accumulation and proteinaceous edema in alveolar spaces in the lungs unlike in control mice

cellular

abnormal cell death ( J:191916 )

• under hyperoxic conditions, lung parenchyma exhibits a 6-fold increase in cell death compared with control cells

Allelic Composition	Keap1^tm1.1Sbis/Keap1^tm1.1Sbis Tg(Scgb1a1-cre)1Grau/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Keap1^tm1.1Sbis mutation (1 available); any Keap1 mutation (34 available)
Tg(Scgb1a1-cre)1Grau mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal lung epithelium morphology ( J:170960 )

• mice exposed to cigarette smoke exhibit reduced respiratory epithelium oxidative stress and inflammation compared with similarly-treated wild-type cells

abnormal club cell morphology ( J:170960 )

• Clara cells exposed to hydrogen peroxide exhibit lower levels of reactive oxygen species compared with similarly-treated wild-type cells

homeostasis/metabolism

decreased susceptibility to injury ( J:170960 )

• mice exposed to cigarette smoke exhibit reduced respiratory epithelium oxidative stress and inflammation compared with similarly-treated wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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