Phenotypes associated with this allele

• Allele Symbol: Metap2^tm1.2Ccr
• Allele Name: targeted mutation 1.2, Craig M Crews
• Allele ID: MGI:3663890
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Metap2^tm1.2Ccr/Metap2^tm1.2Ccr	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:3663891
cx2	Metap2^tm1.2Ccr/Metap2^tm1.2Ccr Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:3663892

Genotype
MGI:3663891

hm1

• Allelic Composition: Metap2^tm1.2Ccr/Metap2^tm1.2Ccr
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:111701 )

• lethality around E8.5

embryo

failure to gastrulate ( J:111701 )

• fail to start gastrulation

embryonic growth arrest ( J:111701 )

• at E7.5, embryos appear to be in the egg-cylinder stage instead of the midgastrulation stage and do not develop beyond the egg-cylinder stage by E8.5

decreased embryo size ( J:111701 )

• consistently reduced in size by E6.5

absent mesoderm ( J:111701 )

• at E7.5, lack a distinct mesoderm, however show normal development of ectoplacental cone, maternal-embryonic interface, ectoderm and endoderm

growth/size/body

decreased embryo size ( J:111701 )

• consistently reduced in size by E6.5

cellular

decreased cell proliferation ( J:111701 )

• E7.5 embryos show decreased cell proliferation

Genotype
MGI:3663892

cx2

• Allelic Composition: Metap2^tm1.2Ccr/Metap2^tm1.2Ccr; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * FVB/N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:111701 )

• develop past gastrulation and survive until E9.5

embryo

decreased embryo size ( J:111701 )

• 6 of 7 E9.5 embryos are smaller than controls but show developed anterior-posterior patterning with head, trunk, and tail region

embryo tissue necrosis ( J:111701 )

• embryos become necrotic around E9.5

growth/size/body

decreased embryo size ( J:111701 )

• 6 of 7 E9.5 embryos are smaller than controls but show developed anterior-posterior patterning with head, trunk, and tail region

cardiovascular system

abnormal vascular development ( J:111701 )

• embryos form an initial vascular network, especially in the brain, however it is less complex than in controls