Phenotypes associated with this allele

• Allele Symbol: Sh3bp2^tm1Geha
• Allele Name: targeted mutation 1, Raif S Geha
• Allele ID: MGI:3664088
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sh3bp2^tm1Geha/Sh3bp2^tm1Geha	Not Specified	MGI:3712861

Genotype
MGI:3712861

hm1

• Allelic Composition: Sh3bp2^tm1Geha/Sh3bp2^tm1Geha
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:110319 )

N • T cell function and T cell receptor signaling are normal in mutants

N • serum levels of immunoglobulins are similar to wild-type

N • antibody responses to T-dependent and T-independent antigens are comparable to wild-type responses; activation of B cells by T-independent antigens is normal in mutants

abnormal B cell number ( J:110319 )

• in mutants, spleen has increased percentage of transitional T1 cells, decreased percentage of T2 cells, and normal numbers of follicular B cells

increased pre-B cell number ( J:110319 )

• increased percentage of B220^lo/IgM^- population in bone marrow which includes pro-B and pre-b cells is observed at 6-10 weeks

• number of pre-B cells is increased ~2-fold in bone marrow compared to wild-type; absolute numbers of pre-B cells in bone marrow of femurs is significantly increased in mice at 6-10 weeks of age

abnormal B cell physiology ( J:110319 )

• spleen has significant decrease in CD23 expression on IgM+ B cells compared to controls; a similar decrease in CD23 expression is seen on peripheral blood B cells

• B cell signaling is impaired in mutants upon BCR ligation

decreased B cell proliferation ( J:110319 )

• significant defect in B cell proliferation is seen upon B cell receptor ligation by IgM

hematopoietic system

abnormal B cell number ( J:110319 )

• in mutants, spleen has increased percentage of transitional T1 cells, decreased percentage of T2 cells, and normal numbers of follicular B cells

increased pre-B cell number ( J:110319 )

• increased percentage of B220^lo/IgM^- population in bone marrow which includes pro-B and pre-b cells is observed at 6-10 weeks

• number of pre-B cells is increased ~2-fold in bone marrow compared to wild-type; absolute numbers of pre-B cells in bone marrow of femurs is significantly increased in mice at 6-10 weeks of age

abnormal B cell physiology ( J:110319 )

• spleen has significant decrease in CD23 expression on IgM+ B cells compared to controls; a similar decrease in CD23 expression is seen on peripheral blood B cells

• B cell signaling is impaired in mutants upon BCR ligation

decreased B cell proliferation ( J:110319 )

• significant defect in B cell proliferation is seen upon B cell receptor ligation by IgM

cellular

decreased B cell proliferation ( J:110319 )

• significant defect in B cell proliferation is seen upon B cell receptor ligation by IgM