About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ccr2tm1Brv
targeted mutation 1, Rodrigo Bravo
MGI:3664108
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ccr2tm1Brv/Ccr2tm1Brv involves: 129S1/Sv * ICR MGI:3665139


Genotype
MGI:3665139
hm1
Allelic
Composition
Ccr2tm1Brv/Ccr2tm1Brv
Genetic
Background
involves: 129S1/Sv * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Brv mutation (0 available); any Ccr2 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ccr2tm1Brv/Ccr2tm1Brv mice are unable to clear Listeria monocytogenes infection

immune system
• 72 hours after peritoneal thioglycollate injection, number of macrophages recovered in peritoneal exudates is one eighth that of wild-type
• number of recruited eosinophils is increased in mutants vs wild-type in response to thioglycollate
• severe multifocal inflammation and necrosis is also observed in spleens of mutants following infection
• at autopsy after bacterial infection, spleens are enlarged and normal in color while wild-type are normal size but mottled in appearance
• severe, multifocal inflammation is observed in mutants
• mutants are unable to clear Listeria monocytogenes infection
• bacterial titers in spleen, liver and lungs of mutants are 3-7 log-fold higher than wild-type 5 days post infection

hematopoietic system
• 72 hours after peritoneal thioglycollate injection, number of macrophages recovered in peritoneal exudates is one eighth that of wild-type
• number of recruited eosinophils is increased in mutants vs wild-type in response to thioglycollate
• severe multifocal inflammation and necrosis is also observed in spleens of mutants following infection
• at autopsy after bacterial infection, spleens are enlarged and normal in color while wild-type are normal size but mottled in appearance

liver/biliary system
• at autopsy after bacterial infection, livers are enlarged and normal in color while wild-type are normal size but mottled in appearance
• severe, multifocal inflammation is observed in mutants
• necrotic lesions are observed after Listeria infection; lesions have central core of coagulative necrosis containing neutrophils, cellular debris and a rim of necrotic hepatocytes with abundant intracellular bacteria

cellular
• 72 hours after peritoneal thioglycollate injection, number of macrophages recovered in peritoneal exudates is one eighth that of wild-type

growth/size/body
• at autopsy after bacterial infection, livers are enlarged and normal in color while wild-type are normal size but mottled in appearance
• at autopsy after bacterial infection, spleens are enlarged and normal in color while wild-type are normal size but mottled in appearance





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory