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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ccr2tm1Brv
targeted mutation 1, Rodrigo Bravo
MGI:3664108
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ccr2tm1Brv/Ccr2tm1Brv involves: 129S1/Sv * ICR MGI:3665139


Genotype
MGI:3665139
hm1
Allelic
Composition
Ccr2tm1Brv/Ccr2tm1Brv
Genetic
Background
involves: 129S1/Sv * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Brv mutation (0 available); any Ccr2 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ccr2tm1Brv/Ccr2tm1Brv mice are unable to clear Listeria monocytogenes infection

immune system
• 72 hours after peritoneal thioglycollate injection, number of macrophages recovered in peritoneal exudates is one eighth that of wild-type
• number of recruited eosinophils is increased in mutants vs wild-type in response to thioglycollate
• severe multifocal inflammation and necrosis is also observed in spleens of mutants following infection
• at autopsy after bacterial infection, spleens are enlarged and normal in color while wild-type are normal size but mottled in appearance
• severe, multifocal inflammation is observed in mutants
• mutants are unable to clear Listeria monocytogenes infection
• bacterial titers in spleen, liver and lungs of mutants are 3-7 log-fold higher than wild-type 5 days post infection

hematopoietic system
• 72 hours after peritoneal thioglycollate injection, number of macrophages recovered in peritoneal exudates is one eighth that of wild-type
• number of recruited eosinophils is increased in mutants vs wild-type in response to thioglycollate
• severe multifocal inflammation and necrosis is also observed in spleens of mutants following infection
• at autopsy after bacterial infection, spleens are enlarged and normal in color while wild-type are normal size but mottled in appearance

liver/biliary system
• at autopsy after bacterial infection, livers are enlarged and normal in color while wild-type are normal size but mottled in appearance
• severe, multifocal inflammation is observed in mutants
• necrotic lesions are observed after Listeria infection; lesions have central core of coagulative necrosis containing neutrophils, cellular debris and a rim of necrotic hepatocytes with abundant intracellular bacteria

cellular
• 72 hours after peritoneal thioglycollate injection, number of macrophages recovered in peritoneal exudates is one eighth that of wild-type

growth/size/body
• at autopsy after bacterial infection, livers are enlarged and normal in color while wild-type are normal size but mottled in appearance
• at autopsy after bacterial infection, spleens are enlarged and normal in color while wild-type are normal size but mottled in appearance





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory