immune system
• 72 hours after peritoneal thioglycollate injection, number of macrophages recovered in peritoneal exudates is one eighth that of wild-type
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• number of recruited eosinophils is increased in mutants vs wild-type in response to thioglycollate
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• severe multifocal inflammation and necrosis is also observed in spleens of mutants following infection
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• at autopsy after bacterial infection, spleens are enlarged and normal in color while wild-type are normal size but mottled in appearance
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• severe, multifocal inflammation is observed in mutants
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• mutants are unable to clear Listeria monocytogenes infection
• bacterial titers in spleen, liver and lungs of mutants are 3-7 log-fold higher than wild-type 5 days post infection
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hematopoietic system
• 72 hours after peritoneal thioglycollate injection, number of macrophages recovered in peritoneal exudates is one eighth that of wild-type
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• number of recruited eosinophils is increased in mutants vs wild-type in response to thioglycollate
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• severe multifocal inflammation and necrosis is also observed in spleens of mutants following infection
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• at autopsy after bacterial infection, spleens are enlarged and normal in color while wild-type are normal size but mottled in appearance
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liver/biliary system
• at autopsy after bacterial infection, livers are enlarged and normal in color while wild-type are normal size but mottled in appearance
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• severe, multifocal inflammation is observed in mutants
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• necrotic lesions are observed after Listeria infection; lesions have central core of coagulative necrosis containing neutrophils, cellular debris and a rim of necrotic hepatocytes with abundant intracellular bacteria
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cellular
• 72 hours after peritoneal thioglycollate injection, number of macrophages recovered in peritoneal exudates is one eighth that of wild-type
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growth/size/body
• at autopsy after bacterial infection, livers are enlarged and normal in color while wild-type are normal size but mottled in appearance
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• at autopsy after bacterial infection, spleens are enlarged and normal in color while wild-type are normal size but mottled in appearance
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