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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
GmnnGt(XT0615)Wtsi
gene trap XT0615, Wellcome Trust Sanger Institute
MGI:3664114
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
GmnnGt(XT0615)Wtsi/GmnnGt(XT0615)Wtsi involves: 129P2/OlaHsd MGI:6470677


Genotype
MGI:6470677
hm1
Allelic
Composition
GmnnGt(XT0615)Wtsi/GmnnGt(XT0615)Wtsi
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GmnnGt(XT0615)Wtsi mutation (0 available); any Gmnn mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygous embryos are detected at E15 or E8.5-9.5; absence of resorbed embryos or empty deciduas suggests preimplantation lethality

embryo
• at E3.5, 70/296 embryos are abnormal, consisting of only eight cells whereas 226/296 had developed into blastocysts consisting of at least 32 cells
• mutant embryos consist of TGCs that can form 8-cell embryos resembling blastocysts with blastocoelic cavities but lacking inner cell mass (ICM)
• in mutant embryos, all cells become committed to trophectoderm lineage

cellular
• nuclei of eight-cell arrested embryos are grossly enlarged and contain three times more DNA than nuclei from wild-type blastocysts at E3.5
• mutant cells undergo endoreduplication, resulting in >3-fold DNA content in mutant nuclei
• all cells lose pleuripotency, endoreduplicate, and consist exclusively of differentiated trophoblast giant cells (TGCs)





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory