All Phenotypes Map3k7<tm1Aki> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Lck-cre)1Jtak/0	involves: 129P2/OlaHsd	MGI:3664612
cn2	Map3k7^tm1Aki/Map3k7^tm1Aki Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(Tek-cre)12Flv/0	involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6	MGI:5464102
cn3	Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Tek-cre)12Flv/0	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:5464101
cn4	Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Lck-cre)1Jtak/0	involves: 129P2/OlaHsd * C57BL/6	MGI:5823990
cn5	Cd19^tm1(cre)Cgn/Cd19⁺ Map3k7^tm1Aki/Map3k7^tm1.1Aki	involves: 129P2/OlaHsd * C57BL/6	MGI:3664610
cn6	Map3k7^tm1Aki/Map3k7^tm1Aki Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:4461042
cn7	Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Slco1c1-icre/ERT2)1Mash/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5305853
cn8	Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Slco1c1-icre/ERT2)1Mash/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5305854
cn9	Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Alb1-cre)7Gsc/0	involves: 129P2/OlaHsd * FVB/N	MGI:4461039
cn10	Ikbkg^tm1.1Chtr/Ikbkg^tm1.1Chtr Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Alb1-cre)7Gsc/0	involves: 129P2/OlaHsd * FVB/N	MGI:4461041
cn11	Casp8^tm1Clie/Casp8^tm1Clie Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Alb1-cre)7Gsc/0	involves: 129P2/OlaHsd * FVB/N	MGI:4461038

Allelic Composition	Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Lck-cre)1Jtak/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7^tm1Aki mutation (0 available); any Map3k7 mutation (54 available)
Tg(Lck-cre)1Jtak mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

colitis ( J:112837 )

• with mononuclear cell infiltration of the colon seen at 4 - 6 months of age

increased memory T cell number ( J:112837 )

• in older mice numbers of activated/memory T cells increases; however, these cells contain only unrecombined alleles

decreased T cell number ( J:112837 )

• markedly reduced numbers of peripheral T cells

• at 4 - 6 months of age almost no naive T cells are found in the spleen and lymph nodes

decreased CD4-positive, alpha-beta T cell number ( J:112837 )

• severe decrease in the number of CD24^low mature cells while the number of CD24^high immature cells is similar to controls

decreased CD8-positive, alpha-beta T cell number ( J:112837 )

• severe decrease in the number of CD24^low mature cells while the number of CD24^high immature cells is similar to controls

absent regulatory T cells ( J:112837 )

• no detectable regulatory T cells in the thymus or spleen at 6 weeks of age

decreased single-positive T cell number ( J:112837 )

• decreased numbers of single positive T cells, especially CD8+ cells, while the numbers of double negative and double positive T cells is similar to controls

abnormal spleen morphology ( J:112837 )

enlarged spleen ( J:112837 )

• seen at 4 - 6 months of age

spleen hyperplasia ( J:112837 )

• increase in the numbers of myeloid lineage cells (macrophages, neutrophils) but almost a complete absence of naive T cells is detected at 4 - 6 months of age

abnormal T cell activation ( J:112837 )

• dose-dependent induction of cell death in response to TNF stimulation unlike controls cells which are viable after TNF stimulation

decreased T cell proliferation ( J:112837 )

• impaired proliferation in response to anti-CD3 stimulation with or without co-stimulation by anti-CD28

enlarged lymph nodes ( J:112837 )

• seen at 4 - 6 months of age

digestive/alimentary system

chronic diarrhea ( J:112837 )

• severe diarrhea beginning at 4 - 6 months of age

abnormal intestine morphology ( J:112837 )

abnormal intestinal goblet cell morphology ( J:112837 )

• at 4 - 6 months of age, loss of goblet cells is seen in the large intestine but not in the small intestine

intestinal ulcer ( J:112837 )

• prominent ulceration is seen at 4 - 6 months of age in the large, but not the small, intestine

abnormal colon morphology ( J:112837 )

• stiff colon present at 4 - 6 months of age

rectal prolapse ( J:112837 )

• seen at 4 - 6 months of age

colitis ( J:112837 )

• with mononuclear cell infiltration of the colon seen at 4 - 6 months of age

growth/size/body

weight loss ( J:112837 )

• begins at 4 - 6 months of age

enlarged spleen ( J:112837 )

• seen at 4 - 6 months of age

spleen hyperplasia ( J:112837 )

• increase in the numbers of myeloid lineage cells (macrophages, neutrophils) but almost a complete absence of naive T cells is detected at 4 - 6 months of age

hematopoietic system

increased memory T cell number ( J:112837 )

• in older mice numbers of activated/memory T cells increases; however, these cells contain only unrecombined alleles

decreased T cell number ( J:112837 )

• markedly reduced numbers of peripheral T cells

• at 4 - 6 months of age almost no naive T cells are found in the spleen and lymph nodes

decreased CD4-positive, alpha-beta T cell number ( J:112837 )

• severe decrease in the number of CD24^low mature cells while the number of CD24^high immature cells is similar to controls

decreased CD8-positive, alpha-beta T cell number ( J:112837 )

• severe decrease in the number of CD24^low mature cells while the number of CD24^high immature cells is similar to controls

absent regulatory T cells ( J:112837 )

• no detectable regulatory T cells in the thymus or spleen at 6 weeks of age

decreased single-positive T cell number ( J:112837 )

• decreased numbers of single positive T cells, especially CD8+ cells, while the numbers of double negative and double positive T cells is similar to controls

abnormal spleen morphology ( J:112837 )

enlarged spleen ( J:112837 )

• seen at 4 - 6 months of age

spleen hyperplasia ( J:112837 )

• increase in the numbers of myeloid lineage cells (macrophages, neutrophils) but almost a complete absence of naive T cells is detected at 4 - 6 months of age

abnormal T cell activation ( J:112837 )

• dose-dependent induction of cell death in response to TNF stimulation unlike controls cells which are viable after TNF stimulation

decreased T cell proliferation ( J:112837 )

• impaired proliferation in response to anti-CD3 stimulation with or without co-stimulation by anti-CD28

cellular

abnormal intestinal goblet cell morphology ( J:112837 )

• at 4 - 6 months of age, loss of goblet cells is seen in the large intestine but not in the small intestine

decreased T cell proliferation ( J:112837 )

• impaired proliferation in response to anti-CD3 stimulation with or without co-stimulation by anti-CD28

Allelic Composition	Map3k7^tm1Aki/Map3k7^tm1Aki Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7^tm1Aki mutation (0 available); any Map3k7 mutation (54 available)
Tg(Tek-cre)12Flv mutation (1 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:191285 )

• mice die by E13.5

cardiovascular system

cardiovascular system phenotype ( J:191285 )

N	• blood vessels do not exhibit regression and exhibit normal vessel length and branching

dilated vasculature ( J:191285 )

cellular

cellular phenotype ( J:191285 )

N	• embryonic endothelial cell apoptosis is rescued

Allelic Composition	Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129P2/OlaHsd * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7^tm1Aki mutation (0 available); any Map3k7 mutation (54 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:191285 )

• mice die between E10.5 and E11.5

cardiovascular system

cardiovascular system phenotype ( J:191285 )

N	• mice exhibit normal cardiac development

abnormal vascular development ( J:191285 )

• defective vascular development at E10.5 with disorganized vasculature and truncated capillary vessels

• however, development of the aorta is normal

decreased angiogenesis ( J:191285 )

• impaired vessel sprouting

abnormal vitelline vasculature morphology ( J:191285 )

• fewer vessel branches

embryo

abnormal vitelline vasculature morphology ( J:191285 )

• fewer vessel branches

cellular

increased apoptosis ( J:191285 )

• in embryonic endothelial cell

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal intestinal epithelium physiology ( J:238318 )

• increase in intestinal epithelial permeability indicating defective barrier function

colitis ( J:238318 )

• mice develop spontaneous colitis

• mice in which gut commensal bacteria is removed by treatment with four antibiotics do not exhibit colitis

• -6-8 week old mutants transferred with TCRalphabeta+CD8alpha+ IELS show significant amelioration of colitis, however transfer with CD8+ T or natural killer cells has no effect on colitis

hematopoietic system

abnormal T cell morphology ( J:238318 )

• drastic reduction in the frequency and absolute number of TCR beta+ T cells in the mesenteric lymph nodes

• however, the colonic lamina propria contains TCR beta+ T cells

• some mice have up to 10 times more T cells in colonic lamina propria than wild-type mice

increased CD4-positive, alpha-beta T cell number ( J:238318 )

• the majority of TCR alpha beta+ T cells in the mesenteric lymph nodes and colonic lamina propria are CD4+ T cells compared to wild-type mice

• accumulation of CD4+ T cells in the colonic lamina propria

decreased NK T cell number ( J:238318 )

• the TCR beta+NK1.1+ natural killer T cell population in the thymus and liver and alpha-GalCer/CD1d-reacted natural killer T cell population in the liver are hardly detectable in mice

abnormal intraepithelial T cell number ( J:238318 )

• reduction in the frequencies and absolute numbers of TCR beta+ intestinal intraepithelial lymphocytes (IEL) in both the small and large intestine

• both the CD8 alpha-alpha+ and CD8 alpha-beta+ cell populations of TCR beta+ IELs are almost completely absent

• the CD4+CD8 alpha-alpha+ cell population in TCR beta+CD8 beta- cells is decreased in the small and large intestine

• the colon exclusive TCR beta+CD4-CD8 alpha-CD8 beta- cell population is absent

• the remaining TCR beta+ IEL fraction is CD4+ T cells

• thymic IEL precursors (TCR alpha-beta+CD4-CD8-NK1.1-) are decreased in both frequency and absolute number; this reduction is due to almost complete loss of CD103+ cell population coexpressing both CD5 and CD122

increased gamma-delta intraepithelial T cell number ( J:238318 )

• increase in the frequency of TCR gamma-delta+ IELs in the small and large intestines and the absolute numbers of these IELs are increased in the colon but not the small intestine

abnormal regulatory T cell number ( J:238318 )

• frequency of regulatory T cells is higher in mesenteric lymph nodes and lower in colonic lamina propria in mice older than 10 weeks of age, however, absolute numbers of regulatory T cells are unchanged

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:238318 )

• reduction in frequency of CD25+Foxp3+ cells in CD4 single positive thymocytes of 10 week old mice that do not have colitis

abnormal alpha-beta intraepithelial T cell morphology ( J:238318 )

• thymic IEL precursors (TCRalphabeta+CD4-CD8-NK1.1-) stimulated with an agonistic anti-CD3 antibody in vitro do not show enlargement of cell size and induced expression of CD25, IL-2Ralpha chain as seen in wild-type cells

• thymic IEL precursors treated with the agonistic anti-CD3 antibody show inefficient induction of CD8alpha induction

abnormal CD4-positive, alpha-beta T cell physiology ( J:238318 )

• CD4+ T cells from colonic lamina propria and mesenteric lymph nodes stimulated with PMA plus ionomycin exhibit a more robust production of IFN-gamma and IL-17A than in wild-type cells

abnormal regulatory T cell physiology ( J:238318 )

• in an in vitro suppression assay, regulatory T cells show less suppressive activity than wild-type T cells, indicating failure of suppressive function of the leaky regulatory T cells

homeostasis/metabolism

abnormal cytokine level ( J:238318 )

• colons show increased mRNA levels of proinflammatory cytokines and RegIII-beta/gamma proteins (antimicrobial peptides)

• elevation of expression of IFN-gamma and IL-17

immune system

colitis ( J:238318 )

• mice develop spontaneous colitis

• mice in which gut commensal bacteria is removed by treatment with four antibiotics do not exhibit colitis

• -6-8 week old mutants transferred with TCRalphabeta+CD8alpha+ IELS show significant amelioration of colitis, however transfer with CD8+ T or natural killer cells has no effect on colitis

abnormal T cell morphology ( J:238318 )

• drastic reduction in the frequency and absolute number of TCR beta+ T cells in the mesenteric lymph nodes

• however, the colonic lamina propria contains TCR beta+ T cells

• some mice have up to 10 times more T cells in colonic lamina propria than wild-type mice

increased CD4-positive, alpha-beta T cell number ( J:238318 )

• the majority of TCR alpha beta+ T cells in the mesenteric lymph nodes and colonic lamina propria are CD4+ T cells compared to wild-type mice

• accumulation of CD4+ T cells in the colonic lamina propria

decreased NK T cell number ( J:238318 )

• the TCR beta+NK1.1+ natural killer T cell population in the thymus and liver and alpha-GalCer/CD1d-reacted natural killer T cell population in the liver are hardly detectable in mice

abnormal intraepithelial T cell number ( J:238318 )

• reduction in the frequencies and absolute numbers of TCR beta+ intestinal intraepithelial lymphocytes (IEL) in both the small and large intestine

• both the CD8 alpha-alpha+ and CD8 alpha-beta+ cell populations of TCR beta+ IELs are almost completely absent

• the CD4+CD8 alpha-alpha+ cell population in TCR beta+CD8 beta- cells is decreased in the small and large intestine

• the colon exclusive TCR beta+CD4-CD8 alpha-CD8 beta- cell population is absent

• the remaining TCR beta+ IEL fraction is CD4+ T cells

increased gamma-delta intraepithelial T cell number ( J:238318 )

• increase in the frequency of TCR gamma-delta+ IELs in the small and large intestines and the absolute numbers of these IELs are increased in the colon but not the small intestine

abnormal regulatory T cell number ( J:238318 )

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:238318 )

• reduction in frequency of CD25+Foxp3+ cells in CD4 single positive thymocytes of 10 week old mice that do not have colitis

abnormal alpha-beta intraepithelial T cell morphology ( J:238318 )

• thymic IEL precursors treated with the agonistic anti-CD3 antibody show inefficient induction of CD8alpha induction

abnormal CD4-positive, alpha-beta T cell physiology ( J:238318 )

• CD4+ T cells from colonic lamina propria and mesenteric lymph nodes stimulated with PMA plus ionomycin exhibit a more robust production of IFN-gamma and IL-17A than in wild-type cells

abnormal regulatory T cell physiology ( J:238318 )

• in an in vitro suppression assay, regulatory T cells show less suppressive activity than wild-type T cells, indicating failure of suppressive function of the leaky regulatory T cells

abnormal cytokine level ( J:238318 )

• colons show increased mRNA levels of proinflammatory cytokines and RegIII-beta/gamma proteins (antimicrobial peptides)

• elevation of expression of IFN-gamma and IL-17

increased interferon-gamma secretion ( J:238318 )

• CD4+ T cells from colonic lamina propria and mesenteric lymph nodes stimulated with PMA plus ionomycin exhibit a more robust production of IFN-gamma than in wild-type cells

increased interleukin-17 secretion ( J:238318 )

• CD4+ T cells from colonic lamina propria and mesenteric lymph nodes stimulated with PMA plus ionomycin exhibit a more robust production of IL-17A than in wild-type cells

liver/biliary system

abnormal liver morphology ( J:238318 )

• large numbers of bacteria are detected in the livers

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Map3k7^tm1Aki/Map3k7^tm1.1Aki
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Map3k7^tm1.1Aki mutation (0 available); any Map3k7 mutation (54 available)
Map3k7^tm1Aki mutation (0 available); any Map3k7 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B-1 B cell number ( J:112597 )

• decrease in the number of B220+CD5+ B-1 B cells in the peritoneal cavity

abnormal B cell physiology ( J:112597 )

• impaired B cell survival following LPS or CpG DNA stimulation or B cell receptor crosslinking

decreased B cell proliferation ( J:112597 )

• decreased LPS- and/or CpG DNA-induced proliferation in follicular and marginal zone B-2 cells with impaired entry in S phase; however, LPS- and/or CpG DNA-induced IL6 production is similar to wild-type

• decreased proliferation in response to B cell receptor and CD40 stimulation with impaired entry into S phase and impaired survival following B cell receptor crosslinking

decreased immunoglobulin level ( J:112597 )

• decrease for all isotypes except IgM

decreased IgG level ( J:112597 )

• decreased levels of IgG1 and IgG3 following T cell dependent or T cell independent antigen stimulation, respectively; however, levels of IgM are similar to control following T cell dependent antigen stimulation

decreased IgG1 level ( J:112597 )

decreased IgG3 level ( J:112597 )

hematopoietic system

decreased B-1 B cell number ( J:112597 )

• decrease in the number of B220+CD5+ B-1 B cells in the peritoneal cavity

abnormal B cell physiology ( J:112597 )

• impaired B cell survival following LPS or CpG DNA stimulation or B cell receptor crosslinking

decreased B cell proliferation ( J:112597 )

• decreased proliferation in response to B cell receptor and CD40 stimulation with impaired entry into S phase and impaired survival following B cell receptor crosslinking

decreased immunoglobulin level ( J:112597 )

• decrease for all isotypes except IgM

decreased IgG level ( J:112597 )

decreased IgG1 level ( J:112597 )

decreased IgG3 level ( J:112597 )

cellular

decreased B cell proliferation ( J:112597 )

• decreased proliferation in response to B cell receptor and CD40 stimulation with impaired entry into S phase and impaired survival following B cell receptor crosslinking

Allelic Composition	Map3k7^tm1Aki/Map3k7^tm1Aki Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7^tm1Aki mutation (0 available); any Map3k7 mutation (54 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

increased hepatocyte proliferation ( J:160521 )

abnormal bile duct morphology ( J:160521 )

• mice exhibit areas of ductopenia within some portal tracts unlike wild-type mice

abnormal hepatocyte morphology ( J:160521 )

focal hepatic necrosis ( J:160521 )

homeostasis/metabolism

increased circulating bilirubin level ( J:160521 )

• mild

endocrine/exocrine glands

abnormal bile duct morphology ( J:160521 )

• mice exhibit areas of ductopenia within some portal tracts unlike wild-type mice

cellular

increased hepatocyte proliferation ( J:160521 )

Allelic Composition	Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Slco1c1-icre/ERT2)1Mash/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7^tm1Aki mutation (0 available); any Map3k7 mutation (54 available)
Tg(Slco1c1-icre/ERT2)1Mash mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:179050 )

N	• intravenous administration of IL-1beta induces reduction in food intake (IL-1beta-induced anorexia over 22 hours; this is similar to response of control mice

lethargy ( J:179050 )

• mutants exhibit reduced lethargy relative to controls in response to intravenous IL-1beta administration

decreased locomotor activity ( J:179050 )

• injection of IL-1beta at 10 am reduced spontaneous locomotion in mutants the next night, response is weaker than in controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:179050 )

N	• mice have normal body temperature • corticosterone plasma levels rise to same extent as controls in response to IL-1beta administration

impaired febrile response ( J:179050 )

• IL-1beta induces only a short-lasting fever response in mutants compared to controls; however, early fever response remains intact

growth/size/body

growth/size/body region phenotype ( J:179050 )

N	• intravenous administration of IL-1beta induces weight loss in mutants over 22 hours; this is similar to response of control mice

Allelic Composition	Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Slco1c1-icre/ERT2)1Mash/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7^tm1Aki mutation (0 available); any Map3k7 mutation (54 available)
Tg(Slco1c1-icre/ERT2)1Mash mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:179050 )

N	• in response to IL-1beta administration, inhibition of locomotion is similar in mutants and controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:179050 )

N	• induced fever response to IL-1beta administration is similar to controls

Allelic Composition	Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7^tm1Aki mutation (0 available); any Map3k7 mutation (54 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:160521 )

• mice die between 14 and 36 weeks

liver/biliary system

increased hepatocyte apoptosis ( J:160521 )

increased hepatocyte proliferation ( J:160521 )

abnormal bile duct morphology ( J:160521 )

• at 6 to 8 weeks, mice lack biliary epithelial cells and regularly shaped small bile ducts compared with wild-type mice

• biliary ductopenia is pronounced within areas of hepatocyte dysplasia

bile duct proliferation ( J:160521 )

liver inflammation ( J:160521 )

abnormal liver morphology ( J:160521 )

• numerous small visible nodules at 6 weeks

• larger nodules and an icteric appearance at 20 weeks

• nodules display cellular features of dysplasia like anisokaryosis unlike wild-type cells

• at 14 weeks, livers exhibit an increase in hydroproline content compared with wild-type liver

abnormal hepatocyte morphology ( J:160521 )

• biliary ductopenia is pronounced within areas of hepatocyte dysplasia

focal hepatic necrosis ( J:160521 )

increased hepatocellular carcinoma incidence ( J:160521 )

• starting at 6 weeks

• in 14 of 16 mice at 16 to 33 weeks

liver fibrosis ( J:160521 )

• at 6 weeks, mice exhibit periportal liver fibrosis unlike wild-type mice

• at 20 to 29 weeks, mice exhibit severe diffuse fibrosis unlike wild-type mice

intrahepatic cholestasis ( J:160521 )

homeostasis/metabolism

increased circulating bilirubin level ( J:160521 )

• at 6 weeks and further at 20 weeks

increased circulating alanine transaminase level ( J:160521 )

• at 6 and 20 weeks

increased circulating alkaline phosphatase level ( J:160521 )

• at 6 weeks

increased circulating aspartate transaminase level ( J:160521 )

• at 6 and 20 weeks

increased circulating glutamate dehydrogenase level ( J:160521 )

• at 6 weeks, circulating glutamate dehydrogenase is increased compared to in wild-type mice

neoplasm

increased hepatocellular carcinoma incidence ( J:160521 )

• starting at 6 weeks

• in 14 of 16 mice at 16 to 33 weeks

immune system

liver inflammation ( J:160521 )

endocrine/exocrine glands

abnormal bile duct morphology ( J:160521 )

• at 6 to 8 weeks, mice lack biliary epithelial cells and regularly shaped small bile ducts compared with wild-type mice

• biliary ductopenia is pronounced within areas of hepatocyte dysplasia

bile duct proliferation ( J:160521 )

cellular

increased hepatocyte apoptosis ( J:160521 )

increased hepatocyte proliferation ( J:160521 )

Allelic Composition	Ikbkg^tm1.1Chtr/Ikbkg^tm1.1Chtr Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkg^tm1.1Chtr mutation (0 available); any Ikbkg mutation (16 available)
Map3k7^tm1Aki mutation (0 available); any Map3k7 mutation (54 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:160521 )

N	• mice exhibit normal survival throughout 50 weeks

liver/biliary system

liver/biliary system phenotype ( J:160521 )

N	• bile ducts are normal at 6 weeks

increased hepatocyte apoptosis ( J:160521 )

increased hepatocyte proliferation ( J:160521 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:160521 )

N	• mice exhibit normal bilirubin serum levels

increased circulating alanine transaminase level ( J:160521 )

increased circulating aspartate transaminase level ( J:160521 )

cellular

increased hepatocyte apoptosis ( J:160521 )

increased hepatocyte proliferation ( J:160521 )

Allelic Composition	Casp8^tm1Clie/Casp8^tm1Clie Map3k7^tm1Aki/Map3k7^tm1Aki Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8^tm1Clie mutation (0 available); any Casp8 mutation (45 available)
Map3k7^tm1Aki mutation (0 available); any Map3k7 mutation (54 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:160521 )

N	• mice exhibit normal survival throughout 40 weeks

liver/biliary system

abnormal bile duct morphology ( J:160521 )

• mice exhibit strong dysplasia, absence of small bile ducts, and increased bile duct proliferation compared with wild-type mice

bile duct proliferation ( J:160521 )

abnormal liver morphology ( J:160521 )

• mice exhibit hyperproliferation, dysplasia, and reduction of biliary epithelial cells unlike wild-type mice

focal hepatic necrosis ( J:160521 )

• at an earlier age and to a larger extent than in Map3k7^tm1Aki/ Map3k7^tm1Aki Tg(Alb1-cre)7Gsc mice

homeostasis/metabolism

increased circulating bilirubin level ( J:160521 )

• serum bilirubin levels are increased compared to in wild-type mice and Map3k7^tm1Aki/ Map3k7^tm1Aki Tg(Alb1-cre)7Gsc mice

increased circulating alanine transaminase level ( J:160521 )

• milder than in Map3k7^tm1Aki/ Map3k7^tm1Aki Tg(Alb1-cre)7Gsc mice

increased circulating aspartate transaminase level ( J:160521 )

growth/size/body

postnatal growth retardation ( J:160521 )

endocrine/exocrine glands

abnormal bile duct morphology ( J:160521 )

• mice exhibit strong dysplasia, absence of small bile ducts, and increased bile duct proliferation compared with wild-type mice

bile duct proliferation ( J:160521 )

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