Analysis Tools|
Allele Symbol Allele Name Allele ID |
Map3k7tm1.1Aki targeted mutation 1.1, Shizuo Akira MGI:3664194 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die between E9.5 and E10.5
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• MEFs from E9.5 embryos fail to grow in culture
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decrease in the number of B220+CD5+ B-1 B cells in the peritoneal cavity
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• impaired B cell survival following LPS or CpG DNA stimulation or B cell receptor crosslinking
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• decreased LPS- and/or CpG DNA-induced proliferation in follicular and marginal zone B-2 cells with impaired entry in S phase; however, LPS- and/or CpG DNA-induced IL6 production is similar to wild-type
• decreased proliferation in response to B cell receptor and CD40 stimulation with impaired entry into S phase and impaired survival following B cell receptor crosslinking
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• decrease for all isotypes except IgM
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• decreased levels of IgG1 and IgG3 following T cell dependent or T cell independent antigen stimulation, respectively; however, levels of IgM are similar to control following T cell dependent antigen stimulation
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• decrease in the number of B220+CD5+ B-1 B cells in the peritoneal cavity
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• impaired B cell survival following LPS or CpG DNA stimulation or B cell receptor crosslinking
|
|
• decreased LPS- and/or CpG DNA-induced proliferation in follicular and marginal zone B-2 cells with impaired entry in S phase; however, LPS- and/or CpG DNA-induced IL6 production is similar to wild-type
• decreased proliferation in response to B cell receptor and CD40 stimulation with impaired entry into S phase and impaired survival following B cell receptor crosslinking
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• decrease for all isotypes except IgM
|
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• decreased levels of IgG1 and IgG3 following T cell dependent or T cell independent antigen stimulation, respectively; however, levels of IgM are similar to control following T cell dependent antigen stimulation
|
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• decreased LPS- and/or CpG DNA-induced proliferation in follicular and marginal zone B-2 cells with impaired entry in S phase; however, LPS- and/or CpG DNA-induced IL6 production is similar to wild-type
• decreased proliferation in response to B cell receptor and CD40 stimulation with impaired entry into S phase and impaired survival following B cell receptor crosslinking
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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