Phenotypes associated with this allele

• Allele Symbol: Pirb^tm1Stz
• Allele Name: targeted mutation 1, Carla J Shatz
• Allele ID: MGI:3664198
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pirb^tm1Stz/Pirb^tm1Stz	involves: 129S4/SvJae * C57BL/6 * FVB	MGI:3664279

Genotype
MGI:3664279

hm1

• Allelic Composition: Pirb^tm1Stz/Pirb^tm1Stz
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:112843 )

N • homozygous mice show enhanced cortical ocular-dominance (OD) plasticity at all ages, particularly during the critical period from postnatal days 22 to P31

abnormal visual cortex morphology ( J:112843 )

• after monocular enucleation (ME) from P22-P31, the ipsilateral eye shows greater width of thalamocortical connections in layer 4; width of Arc induction in layer 4 of the binocular zone (BZ) is 22% (P31-P36) to 54% (P19-P25) greater vs wild-type mice and expansion of Arc induction is greater at P100-P110 compared to wild-type (after ME)

• after monocular deprivation (MD) by eyelid suture from P19-25, width of Arc induction is 17% greater than in wild-type

• after ME on mice at P25, analysis at P40 shows an 18% wider area of layer 4 receiving inputs from lateral geniculate neurons (thalamocortical connections) in mutants vs wild-type