Phenotypes associated with this allele

• Allele Symbol: Me1ⁿ
• Allele Name: null
• Allele ID: MGI:3664328
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Me1^n/Me1^n	involves: C57BL/6J	MGI:3848615
hm2	Me1^n/Me1^n	involves: C57BL/6J * DBA/2J	MGI:3687986
ht3	Me1^n/Me1^+	involves: C57BL/6J * DBA/2J	MGI:3687987

Genotype
MGI:3848615

hm1

• Allelic Composition: Me1ⁿ/Me1ⁿ
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal food intake ( J:148831 )

• males on a high fat diet show significant differences (decreased food intake) relative to controls

growth/size/body

decreased body weight ( J:148831 )

• males and females on a medium high fat diet (44.9% kcal from fat) show decreased body weight

Genotype
MGI:3687986

hm2

• Allelic Composition: Me1ⁿ/Me1ⁿ
• Genetic Background: involves: C57BL/6J * DBA/2J

mortality/aging

mortality/aging ( J:6579 )

N • number of homozygous females (~33%) is lower than expected (~50%), possibly indicating a detrimental effect of the mutant allele, expressed early in development

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:6579 )

• mice have very low cytoplasmic malic enzyme activity (<0.10) compared to wild-type homozygous for the DBA/2J (variant a) form (1.10) or the C57BL/6J (variant b) form (0.50)

Genotype
MGI:3687987

ht3

• Allelic Composition: Me1ⁿ/Me1⁺
• Genetic Background: involves: C57BL/6J * DBA/2J

mortality/aging

mortality/aging ( J:6579 )

N • males heterozygous for Mod1 and the C57BL/6 wild-type allele are present at a significantly lower frequency (males 33% vs females 67%) than expected (50%:50%), possibly indicating a detrimental effect of the mutant allele, expressed early in development

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:6579 )

• male mice have ~50% of normal levels of cytoplasmic malic enzyme activity (0.60) while females have ~25% (0.25) compared to wild-type mice homozygous for the DBA/2J (variant a) form (1.10) or the C57BL/6J (variant b) form (0.50)