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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr5tm1Aki
targeted mutation 1, Shizuo Akira
MGI:3664436
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr5tm1Aki/Tlr5tm1Aki B6.129P2-Tlr5tm1Aki MGI:3696115
hm2
 		Tlr5tm1Aki/Tlr5tm1Aki involves: 129P2/OlaHsd MGI:5751563
hm3
 		Tlr5tm1Aki/Tlr5tm1Aki involves: 129P2/OlaHsd * C57BL/6 MGI:3706949


Genotype
MGI:3696115
hm1
Allelic
Composition		 Tlr5tm1Aki/Tlr5tm1Aki
Genetic
Background		 B6.129P2-Tlr5tm1Aki
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr5tm1Aki mutation (1 available); any Tlr5 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:116763 )
N
• no resistance to cerebral malaria
decreased interleukin-12b secretion ( J:112391 )
• serum levels of IL-12b fail to rise after IP injection of purified flagellin
• failure of the lamina propria cells of the intestine to produce IL-12b
decreased interleukin-6 secretion ( J:112391 )
• serum levels of IL-6 fail to rise after IP injection of purified flagellin
• failure of the lamina propria cells of the intestine to produce IL-6
decreased susceptibility to bacterial infection ( J:112391 )
• resistant to infection by Salmonella typhimurium




Genotype
MGI:5751563
hm2
Allelic
Composition		 Tlr5tm1Aki/Tlr5tm1Aki
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr5tm1Aki mutation (1 available); any Tlr5 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal gut flora balance ( J:229155 )
• delayed clearance of pathobiont bacteria
increased susceptibility to colitis induced morbidity/mortality ( J:229155 )
• mice die with 20 days of DSS treatment

hematopoietic system
enlarged spleen ( J:229155 )
• mild splenomegaly

immune system
increased susceptibility to colitis induced morbidity/mortality ( J:229155 )
• mice die with 20 days of DSS treatment
enlarged spleen ( J:229155 )
• mild splenomegaly
increased interleukin-1 beta secretion ( J:229155 )
• increased levels of colonic ILB secretion in males treated with DSS

mortality/aging
increased susceptibility to colitis induced morbidity/mortality ( J:229155 )
• mice die with 20 days of DSS treatment

growth/size/body
enlarged spleen ( J:229155 )
• mild splenomegaly




Genotype
MGI:3706949
hm3
Allelic
Composition		 Tlr5tm1Aki/Tlr5tm1Aki
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr5tm1Aki mutation (1 available); any Tlr5 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:112671 )
• treatment of macrophages with purified flagellin in the absence of DOTAP which mediates protein delivery into the cytosol does not produce activation of Casp1, indicating that intracellular presence of flagellin is required for normal response to bacterial infection

hematopoietic system
abnormal macrophage physiology ( J:112671 )
• treatment of macrophages with purified flagellin in the absence of DOTAP which mediates protein delivery into the cytosol does not produce activation of Casp1, indicating that intracellular presence of flagellin is required for normal response to bacterial infection




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/24/2024
MGI 6.24 		The Jackson Laboratory