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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cyldtm1Scs
targeted mutation 1, Shao-Cong Sun
MGI:3664438
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cyldtm1Scs/Cyldtm1Scs involves: 129S1/Sv * 129X1/SvJ MGI:3706342
cx2
 		Cyldtm1Scs/Cyldtm1Scs
Ripk3tm2Vmd/Ripk3tm2Vmd 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6N MGI:5614636


Genotype
MGI:3706342
hm1
Allelic
Composition		 Cyldtm1Scs/Cyldtm1Scs
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyldtm1Scs mutation (0 available); any Cyld mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:112392 )
• B cell compartment in mutants is slighter larger than in wild-type
abnormal T cell number ( J:112392 )
• double positive cells are increased in proportion while single positive CD4 or CD8 cell proportion is decreased in mutants
decreased CD4-positive, alpha-beta T cell number ( J:112392 )
• mice have fewer splenic CD4+ T cells than wild-type
decreased CD8-positive, alpha-beta T cell number ( J:112392 )
• mice have fewer splenic CD8+ T cells than wild-type

hematopoietic system
abnormal B cell differentiation ( J:112392 )
• B cell compartment in mutants is slighter larger than in wild-type
abnormal T cell number ( J:112392 )
• double positive cells are increased in proportion while single positive CD4 or CD8 cell proportion is decreased in mutants
decreased CD4-positive, alpha-beta T cell number ( J:112392 )
• mice have fewer splenic CD4+ T cells than wild-type
decreased CD8-positive, alpha-beta T cell number ( J:112392 )
• mice have fewer splenic CD8+ T cells than wild-type

homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:112392 )
• phosphorylation of Erk, Lat and Zap70 by Cyld is attenuated in purified double positive thymocytes




Genotype
MGI:5614636
cx2
Allelic
Composition		 Cyldtm1Scs/Cyldtm1Scs
Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyldtm1Scs mutation (0 available); any Cyld mutation (44 available)
Ripk3tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality prior to tooth bud stage ( J:209137 )
• embryos do not survive beyond around E11.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory