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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nr1h3tm1Dgen
targeted mutation 1, Deltagen
MGI:3664445
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nr1h3tm1Dgen/Nr1h3tm1Dgen Not Specified MGI:3688386


Genotype
MGI:3688386
hm1
Allelic
Composition		 Nr1h3tm1Dgen/Nr1h3tm1Dgen
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1h3tm1Dgen mutation (0 available); any Nr1h3 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid homeostasis ( J:112995 )
• high-cholesterol fed mutants infused with tauroursodeoxycholate to determine maximal secretory rates for biliary lipids exhibit slightly higher bile flows and a 200% increase in hepatobiliary excretion of phospholipids compared to wild-type but similar cholesterol secretion rates
abnormal cholesterol homeostasis ( J:112995 )
• cholesterol feeding increases hepatobiliary cholesterol (sterol ester) excretion to a higher level than in wild-type

liver/biliary system
abnormal hepatobiliary system physiology ( J:112995 )
• cholesterol feeding increases hepatobiliary cholesterol (sterol ester) excretion to a higher level than in wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory