Phenotypes associated with this allele

• Allele Symbol: Chst5^tm1Knsh
• Allele Name: targeted mutation 1, Kohji Nishida
• Allele ID: MGI:3664471
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chst5^tm1Knsh/Chst5^tm1Knsh	B6.129-Chst5^tm1Knsh	MGI:3687222

Genotype
MGI:3687222

hm1

• Allelic Composition: Chst5^tm1Knsh/Chst5^tm1Knsh
• Genetic Background: B6.129-Chst5^tm1Knsh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Corneas of wild type, Chst5^tm1Knsh/Chst5⁺ and Chst5^tm1Knsh/Chst5^tm1Knsh mice

vision/eye

abnormal cornea morphology ( J:112899 )

• corneas lack high-sulfated keratan sulfate but contain the core protein of the major keratan sulfate proteoglycan, lumican

• abnormally large chondroitin sulfate/dermatan sulfate proteoglycan complexes are abundant throughout the cornea, indicating altered control of proteoglycan production

decreased cornea thickness ( J:112899 )

abnormal cornea stroma morphology ( J:112899 )

• corneal stroma exhibits widespread structural alterations in collagen fibrillar architecture, including a decrease in interfibrillar spacing and a more spatially disorganized collagen array

decreased cornea stroma thickness ( J:112899 )