Phenotypes associated with this allele

• Allele Symbol: Apobec1^tm1Ishi
• Allele Name: targeted mutation 1, Shun Ishibashi
• Allele ID: MGI:3664540
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apobec1^tm1Ishi/Apobec1^tm1Ishi	involves: 129S7/SvEvBrd * C57BL/6	MGI:3710349
cx2	Apobec1^tm1Ishi/Apobec1^tm1Ishi Apoe^tm1Unc/Apoe^tm1Unc	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:3710350

Genotype
MGI:3710349

hm1

• Allelic Composition: Apobec1^tm1Ishi/Apobec1^tm1Ishi
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:41982 )

• plasma cholesterol levels are lower (71.0+/-3.7mg/dl) than in heterozygous mice (84.6+/-2.1/dl)

increased cholesterol level ( J:41982 )

• non-high density lipoproteins (HDL) cholesterol in plasma is significantly greater (28.5+/-1.7%) than in wild-type mice (22.6+/-1.3%)

• however, plasma triglyceride levels are not significantly different than in wild-type mice

Genotype
MGI:3710350

cx2

• Allelic Composition: Apobec1^tm1Ishi/Apobec1^tm1Ishi; Apoe^tm1Unc/Apoe^tm1Unc
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

homeostasis/metabolism

decreased circulating cholesterol level ( J:41982 )

• plasma cholesterol levels are lower (436.5+/-59.2mg/dl) than in Apoe^tm1Unc homozygotes (621.5+/-126.7mg/dl)

increased circulating triglyceride level ( J:41982 )

• plasma levels of triglycerides are greater (238.0+/-113.3%) than in the Apoe^tm1Unc homozygote (98.1+/-91.1%)