Phenotypes associated with this allele

• Allele Symbol: Gli2^tm6.1Alj
• Allele Name: targeted mutation 6.1, Alexandra L Joyner
• Allele ID: MGI:3664542
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gli2^tm6.1Alj/Gli2^tm6.1Alj	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * SJL	MGI:3665553
ht2	Gli2^tm1Alj/Gli2^tm6.1Alj	involves: 129/Sv * C57BL/6 * SJL	MGI:3665554

Genotype
MGI:3665553

hm1

• Allelic Composition: Gli2^tm6.1Alj/Gli2^tm6.1Alj
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:108507 )

• lethality at birth is observed

nervous system

abnormal cerebellar foliation ( J:108507 )

• cerebellum has abnormal foliation that is more pronounced posteriorly; foliation is reduced

reduced cerebellar foliation ( J:108507 )

thin external granule cell layer ( J:108507 )

• in anterior and posterior regions of cerebellum, external granule layer (EGL) contains only 2-4 cell layers in contrast to wild-type where there are 5-8 layers

hydrocephaly ( J:108507 )

• seen in E18.5 embryos

small cerebellum ( J:108507 )

• smaller than in wild-type

embryo

abnormal developmental patterning ( J:108507 )

• at E10.5, patterning of ventral spinal cord is abnormal

abnormal rostral-caudal axis patterning ( J:108507 )

• at E18.5, body axis is curved

Genotype
MGI:3665554

ht2

• Allelic Composition: Gli2^tm1Alj/Gli2^tm6.1Alj
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

mortality/aging

perinatal lethality, complete penetrance ( J:108507 )

• lethality at birth is observed

embryo

abnormal developmental patterning ( J:108507 )

• at E10.5, patterning of ventral spinal cord is abnormal

abnormal rostral-caudal axis patterning ( J:108507 )

• at E18.5, body axis is curved

nervous system

abnormal cerebellar foliation ( J:108507 )

• cerebellum has abnormal foliation that is more pronounced posteriorly; foliation is reduced

reduced cerebellar foliation ( J:108507 )

thin external granule cell layer ( J:108507 )

• in anterior and posterior regions of cerebellum, external granule layer (EGL) contains only 2-4 cell layers in contrast to wild-type where there are 5-8 layers

hydrocephaly ( J:108507 )

• seen in E18.5 embryos

small cerebellum ( J:108507 )

• smaller than in wild-type