Phenotypes associated with this allele

• Allele Symbol: Klhl1/Atxn8os^tm1.1Mdk
• Allele Name: targeted mutation 1.1, Michael D Koob
• Allele ID: MGI:3664543
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klhl1/Atxn8os^tm1.1Mdk/Klhl1/Atxn8os^tm1.1Mdk	involves: 129S1/Sv * C57BL/6 * FVB/N * SJL	MGI:3689864
ht2	Klhl1/Atxn8os^tm1.1Mdk/Klhl1/Klhl1as^+	involves: 129S1/Sv * C57BL/6 * FVB/N * SJL	MGI:3689871

Genotype
MGI:3689864

hm1

• Allelic Composition: Klhl1/Atxn8os^tm1.1Mdk/Klhl1/Atxn8os^tm1.1Mdk
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:112937 )

• rotarod deficits are significant at 18 weeks and later

abnormal gait ( J:112937 )

• appears by 4 weeks of age

• longer stance time and longer stride time

• both fore and hind paws are affected but more pronounced in hind paws

nervous system

thin cerebellar molecular layer ( J:112937 )

• layer normal at 6 weeks but definitely thinner at 24 weeks of age

• dendritic atrophy of Purkinje cells seen but Purkinje cells themselves display an overall normal morphology

Genotype
MGI:3689871

ht2

• Allelic Composition: Klhl1/Atxn8os^tm1.1Mdk/Klhl1/Klhl1as⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

behavior/neurological

impaired coordination ( J:112937 )

• rotarod deficits are apparent but not significant at 18 weeks

• loss of motor coordination becomes significant at 24 weeks of age

abnormal gait ( J:112937 )

• both fore and hind paws are affected but more pronounced in hind paws

• appears by 4 weeks of age

• longer stride time only

nervous system

thin cerebellar molecular layer ( J:112937 )

• layer normal at 6 weeks but definitely thinner at 24 weeks of age

• dendritic atrophy of Purkinje cells seen but Purkinje cells themselves display an overall normal morphology