hematopoietic system
• number of dendritic cells in the spleen expressing class II molecules is 3-5-fold reduced compared to wild-type, and numbers in the lymph nodes are even more reduced
|
• numbers of CD4+CD8- tymocytes are reduced compared to wild-type
• CD/CD8 profiles show a significant number of mature CD4+CD8- cells, but levels are still 6-fold lower than in wild-type
|
immune system
• number of dendritic cells in the spleen expressing class II molecules is 3-5-fold reduced compared to wild-type, and numbers in the lymph nodes are even more reduced
|
• numbers of CD4+CD8- tymocytes are reduced compared to wild-type
• CD/CD8 profiles show a significant number of mature CD4+CD8- cells, but levels are still 6-fold lower than in wild-type
|
• macrophages from mutant mice fail to display class II molecules
• level of class II molecules in lymph nodes is less than in control littermates (by 3- to 5-fold)
|