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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ciitatm1.1Dim
targeted mutation 1.1, Diane Mathis
MGI:3664552
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ciitatm1.1Dim/Ciitatm1.1Dim involves: 129S2/SvPas * C57BL/6 * SJL MGI:3707206


Genotype
MGI:3707206
hm1
Allelic
Composition
Ciitatm1.1Dim/Ciitatm1.1Dim
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ciitatm1.1Dim mutation (0 available); any Ciita mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• number of dendritic cells in the spleen expressing class II molecules is 3-5-fold reduced compared to wild-type, and numbers in the lymph nodes are even more reduced
• numbers of CD4+CD8- tymocytes are reduced compared to wild-type
• CD/CD8 profiles show a significant number of mature CD4+CD8- cells, but levels are still 6-fold lower than in wild-type

immune system
• number of dendritic cells in the spleen expressing class II molecules is 3-5-fold reduced compared to wild-type, and numbers in the lymph nodes are even more reduced
• numbers of CD4+CD8- tymocytes are reduced compared to wild-type
• CD/CD8 profiles show a significant number of mature CD4+CD8- cells, but levels are still 6-fold lower than in wild-type
• macrophages from mutant mice fail to display class II molecules
• level of class II molecules in lymph nodes is less than in control littermates (by 3- to 5-fold)





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory